Regional longitudinal strain patterns according to left ventricular hypertrophy in the general population

Katrine Emilie Frimodt-Møller*, Flemming Javier Olsen, Sofie Reumert Biering-Sørensen, Mats Christian Højbjerg Lassen, Rasmus Møgelvang, Peter Schnohr, Gorm Jensen, Gunnar Gislason, Gregory Maurice Marcus, Tor Biering-Sørensen

*Corresponding author for this work

Abstract

AIMS: A pattern of reduced basal longitudinal strain (BLS) is often observed with left ventricular (LV) hypertrophy (LVH). Whether this pattern is associated with poor outcome is unclear. We aimed to evaluate the prognostic value of regional longitudinal strain according to LV geometry.

METHODS AND RESULTS: We investigated participants in the 4th Copenhagen City Heart Study who had an echocardiogram with speckle tracking performed. Participants were stratified according to the presence of LVH (LV mass index ≥116 g/m2 for men and ≥96 g/m2 for women). The outcome was major adverse cardiovascular events (MACE) defined as a composite of myocardial infarction, heart failure, and/or cardiovascular death. The study population consisted of 1090 participants. Mean LVEF was 60% and 160 (15%) had LVH. During a median follow-up of 14.7 years, there were 137 events. Both BLS and midventricular strain, but not apical strain, became incrementally impaired in the spectrum from normal to hypertensives subjects without LVH, and to participants with hypertension and LVH. After multivariable adjustment, BLS and midventricular strain were independently associated with MACE in participants with LVH (BLS: HR 1.08, 95% CI 1.00-1.17, P = 0.041; midventricular strain: HR 1.10, 95% CI 1.00-1.21, P = 0.041) but not in participants without LVH (BLS: HR 0.96, 95% CI 0.90-1.01, P = 0.13; midventricular strain: HR 0.97, 95% CI 0.91-1.03, P = 0.36).

CONCLUSION: BLS and midventricular strain, but not apical strain, become incrementally impaired in the spectrum from normal geometry to LVH, and are independently associated with MACE in participants with LVH.

Original languageEnglish
JournalEuropean Heart Journal Cardiovascular Imaging
Volume23
Issue number11
Pages (from-to)1436-1444
Number of pages9
ISSN1525-2167
DOIs
Publication statusPublished - 20 Oct 2022

Keywords

  • Echocardiography/methods
  • Female
  • Heart Failure/complications
  • Humans
  • Hypertension/complications
  • Hypertrophy, Left Ventricular/diagnostic imaging
  • Male
  • Prognosis

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