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Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1-5: a cross-sectional study of the Copenhagen chronic kidney disease cohort

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@article{6320b11d5f044c3792b18314b8ab8c63,
title = "Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1-5: a cross-sectional study of the Copenhagen chronic kidney disease cohort",
abstract = "BACKGROUND: Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD.METHODS: This was an observational, cross-sectional study that included 580 individuals with CKD stages 1-5 (no dialysis) from the Copenhagen CKD Cohort. Calcification of the carotid, coronary and iliac arteries, thoracic and abdominal aorta was assessed using non-contrast multidetector computed tomography scans and quantified according to the Agatston method. Based on the distribution of Agatston scores in the selected arterial region, the subjects were divided into calcium score categories of 0 (no calcification), 1-100, 101-400 and > 400.RESULTS: Participants with CKD stages 3-5 had the highest prevalence of calcification and the highest frequency of calcium scores > 400 in all arterial sites. Calcification in at least one arterial site was present in > 90% of patients with CKD stage 3. In all five CKD stages prevalence of calcification was greatest in both the thoracic and abdominal aorta, and in the iliac arteries. These arterial sites also showed the highest calcium scores. High calcium scores (> 400) in all five arterial regions were independently associated with prevalent cardiovascular disease. In multivariable analyses, after adjusting for cardiovascular risk factors, declining creatinine clearance was associated with increasing calcification of the coronary arteries (p = 0.012) and the thoracic aorta (p = 0.037) only.CONCLUSIONS: Arterial calcification is highly prevalent throughout all five CKD stages and is most prominent in both the thoracic and abdominal aorta, and in the iliac arteries. Follow-up studies are needed to explore the potential of extracardiac calcification sites in prediction of cardiovascular events in the CKD population.",
keywords = "Abdominal aorta, Arterial calcification, Calcium score, Cardiovascular disease, Carotid arteries, Chronic kidney disease, Coronary arteries, Iliac arteries, Thoracic aorta, Vascular calcification",
author = "S{\o}rensen, {Ida Maria Hjelm} and Saurbrey, {Sasha Asb{\o}ll Kepler} and Hjortkj{\ae}r, {Henrik {\O}der} and Philip Brainin and Nicholas Carlson and Ballegaard, {Ellen Linnea Freese} and Anne-Lise Kamper and Christina Christoffersen and Bo Feldt-Rasmussen and Kofoed, {Klaus Fuglsang} and Susanne Bro",
year = "2020",
month = dec,
day = "9",
doi = "10.1186/s12882-020-02192-y",
language = "English",
volume = "21",
pages = "534",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1-5

T2 - a cross-sectional study of the Copenhagen chronic kidney disease cohort

AU - Sørensen, Ida Maria Hjelm

AU - Saurbrey, Sasha Asbøll Kepler

AU - Hjortkjær, Henrik Øder

AU - Brainin, Philip

AU - Carlson, Nicholas

AU - Ballegaard, Ellen Linnea Freese

AU - Kamper, Anne-Lise

AU - Christoffersen, Christina

AU - Feldt-Rasmussen, Bo

AU - Kofoed, Klaus Fuglsang

AU - Bro, Susanne

PY - 2020/12/9

Y1 - 2020/12/9

N2 - BACKGROUND: Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD.METHODS: This was an observational, cross-sectional study that included 580 individuals with CKD stages 1-5 (no dialysis) from the Copenhagen CKD Cohort. Calcification of the carotid, coronary and iliac arteries, thoracic and abdominal aorta was assessed using non-contrast multidetector computed tomography scans and quantified according to the Agatston method. Based on the distribution of Agatston scores in the selected arterial region, the subjects were divided into calcium score categories of 0 (no calcification), 1-100, 101-400 and > 400.RESULTS: Participants with CKD stages 3-5 had the highest prevalence of calcification and the highest frequency of calcium scores > 400 in all arterial sites. Calcification in at least one arterial site was present in > 90% of patients with CKD stage 3. In all five CKD stages prevalence of calcification was greatest in both the thoracic and abdominal aorta, and in the iliac arteries. These arterial sites also showed the highest calcium scores. High calcium scores (> 400) in all five arterial regions were independently associated with prevalent cardiovascular disease. In multivariable analyses, after adjusting for cardiovascular risk factors, declining creatinine clearance was associated with increasing calcification of the coronary arteries (p = 0.012) and the thoracic aorta (p = 0.037) only.CONCLUSIONS: Arterial calcification is highly prevalent throughout all five CKD stages and is most prominent in both the thoracic and abdominal aorta, and in the iliac arteries. Follow-up studies are needed to explore the potential of extracardiac calcification sites in prediction of cardiovascular events in the CKD population.

AB - BACKGROUND: Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD.METHODS: This was an observational, cross-sectional study that included 580 individuals with CKD stages 1-5 (no dialysis) from the Copenhagen CKD Cohort. Calcification of the carotid, coronary and iliac arteries, thoracic and abdominal aorta was assessed using non-contrast multidetector computed tomography scans and quantified according to the Agatston method. Based on the distribution of Agatston scores in the selected arterial region, the subjects were divided into calcium score categories of 0 (no calcification), 1-100, 101-400 and > 400.RESULTS: Participants with CKD stages 3-5 had the highest prevalence of calcification and the highest frequency of calcium scores > 400 in all arterial sites. Calcification in at least one arterial site was present in > 90% of patients with CKD stage 3. In all five CKD stages prevalence of calcification was greatest in both the thoracic and abdominal aorta, and in the iliac arteries. These arterial sites also showed the highest calcium scores. High calcium scores (> 400) in all five arterial regions were independently associated with prevalent cardiovascular disease. In multivariable analyses, after adjusting for cardiovascular risk factors, declining creatinine clearance was associated with increasing calcification of the coronary arteries (p = 0.012) and the thoracic aorta (p = 0.037) only.CONCLUSIONS: Arterial calcification is highly prevalent throughout all five CKD stages and is most prominent in both the thoracic and abdominal aorta, and in the iliac arteries. Follow-up studies are needed to explore the potential of extracardiac calcification sites in prediction of cardiovascular events in the CKD population.

KW - Abdominal aorta

KW - Arterial calcification

KW - Calcium score

KW - Cardiovascular disease

KW - Carotid arteries

KW - Chronic kidney disease

KW - Coronary arteries

KW - Iliac arteries

KW - Thoracic aorta

KW - Vascular calcification

UR - http://www.scopus.com/inward/record.url?scp=85097443102&partnerID=8YFLogxK

U2 - 10.1186/s12882-020-02192-y

DO - 10.1186/s12882-020-02192-y

M3 - Journal article

C2 - 33297991

VL - 21

SP - 534

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 534

ER -

ID: 61546484