Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1-5: a cross-sectional study of the Copenhagen chronic kidney disease cohort

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Does conservative kidney management offer a quantity or quality of life benefit compared to dialysis? A systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Left-sided heart disease and risk of death in patients with end-stage kidney disease receiving haemodialysis: an observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Choice of dialysis modality: patients' experiences and quality of decision after shared decision-making

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Pulmonary artery pressure as a method for assessing hydration status in an anuric hemodialysis patient - a case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Patient-Specific Implantation Technique to Obtain Neo-Commissural Alignment With Self-Expanding Transcatheter Aortic Valves

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system

    Research output: Contribution to journalReviewResearchpeer-review

  3. Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 promote the transendothelial transport of High-Density Lipoprotein

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Heart failure associated with imported malaria: a nationwide Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD.

METHODS: This was an observational, cross-sectional study that included 580 individuals with CKD stages 1-5 (no dialysis) from the Copenhagen CKD Cohort. Calcification of the carotid, coronary and iliac arteries, thoracic and abdominal aorta was assessed using non-contrast multidetector computed tomography scans and quantified according to the Agatston method. Based on the distribution of Agatston scores in the selected arterial region, the subjects were divided into calcium score categories of 0 (no calcification), 1-100, 101-400 and > 400.

RESULTS: Participants with CKD stages 3-5 had the highest prevalence of calcification and the highest frequency of calcium scores > 400 in all arterial sites. Calcification in at least one arterial site was present in > 90% of patients with CKD stage 3. In all five CKD stages prevalence of calcification was greatest in both the thoracic and abdominal aorta, and in the iliac arteries. These arterial sites also showed the highest calcium scores. High calcium scores (> 400) in all five arterial regions were independently associated with prevalent cardiovascular disease. In multivariable analyses, after adjusting for cardiovascular risk factors, declining creatinine clearance was associated with increasing calcification of the coronary arteries (p = 0.012) and the thoracic aorta (p = 0.037) only.

CONCLUSIONS: Arterial calcification is highly prevalent throughout all five CKD stages and is most prominent in both the thoracic and abdominal aorta, and in the iliac arteries. Follow-up studies are needed to explore the potential of extracardiac calcification sites in prediction of cardiovascular events in the CKD population.

Original languageEnglish
Article number534
JournalBMC Nephrology
Volume21
Issue number1
Pages (from-to)534
ISSN1471-2369
DOIs
Publication statusPublished - 9 Dec 2020

    Research areas

  • Abdominal aorta, Arterial calcification, Calcium score, Cardiovascular disease, Carotid arteries, Chronic kidney disease, Coronary arteries, Iliac arteries, Thoracic aorta, Vascular calcification

ID: 61546484