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Regional differences in turnover, composition, and mechanics of the porcine flexor tendon

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  1. Characterization of miRNA expression in human degenerative lumbar disks

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  2. Tensile force transmission in human patellar tendon fascicles is not mediated by glycosaminoglycans

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  3. Expression, content, and localization of insulin-like growth factor I in human achilles tendon

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  1. Maintenance of muscle strength following a one-year resistance training program in older adults

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  2. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

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  3. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

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  4. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

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  5. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

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Purpose: Recent data suggest that there is a lack of turnover in the core of human tendon, but it remains unknown whether there are regional differences between core and periphery of the cross section. The purpose of this project was to investigate regional differences in turnover as estimated by the accumulation of fluorescent Advanced Glycation End-products (AGEs) and regional differences in mechanical properties. Materials and methods: Tendons were obtained from lean control (n = 4) and diabetic Göttingen minipigs (streptozotocin-induced, n = 6). The deep digital flexor tendon of one hind limb was separated into a proximal, central and distal part. Autofluorescence was measured in the core and periphery of the proximal and distal parts of the tendon, and mechanical properties were tested on fascicles taken from the core and periphery of the central tendon (only diabetic animals). Results: Autofluorescence was greater in the proximal than the distal part. In the distal part of the lean control animals, autofluorescent AGE accumulation was also greater in the core than the periphery. Peak modulus in the core region (704 ± 79 MPa) was higher than the periphery (466 ± 53 MPa, p < 0.05) in diabetic tendons. Conclusion: Taken together, autofluorescence varied both along the length and across the tendon cross section, indicating higher turnover in the distal and peripheral regions. In addition, mechanical properties differed across the tendon cross-section.

Original languageEnglish
JournalConnective Tissue Research
Number of pages10
ISSN0300-8207
DOIs
Publication statusPublished - 2019

ID: 58971953