Reduction of oxidative DNA-damage in humans by brussels sprouts

H Verhagen, H E Poulsen, S Loft, G van Poppel, M I Willems, P J van Bladeren


The effect of consumption of Brussels sprouts on levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in human urine was investigated in 10 healthy, male, non-smoking volunteers. Following a 3 week run-in period, five volunteers continued on a diet free of cruciferous vegetables for a subsequent 3 week intervention period (control group), while the other five (sprouts group) consumed 300 g of cooked Brussels sprouts per day, at the expense of 300 g of a glucosinolate-free vegetable. Levels of 8-oxodG in 24 h urine samples were measured by HPLC. In the control group there was no difference between the two periods in levels of 8-oxodG (P = 0.72). In contrast, in the sprouts group the levels of 8-oxodG were decreased by 28% during the intervention period (P = 0.039). The present findings support the results of epidemiologic studies that consumption of cruciferous vegetables may result in a decreased cancer risk.

Original languageEnglish
Issue number4
Pages (from-to)969-70
Number of pages2
Publication statusPublished - Apr 1995


  • 8-Hydroxy-2'-Deoxyguanosine
  • Anticarcinogenic Agents/therapeutic use
  • Antimutagenic Agents/therapeutic use
  • Antioxidants/therapeutic use
  • Brassica
  • DNA/drug effects
  • DNA Damage
  • Deoxyguanosine/analogs & derivatives
  • Diet
  • Humans
  • Male
  • Oxidation-Reduction
  • Vegetables


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