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Reduced levels of pulmonary surfactant in COVID-19 ARDS

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Schousboe, Peter ; Ronit, Andreas ; Nielsen, Henning B ; Benfield, Thomas ; Wiese, Lothar ; Scoutaris, Nikolaos ; Verder, Henrik ; Berg, Ronan M G ; Verder, Povl ; Plovsing, Ronni R. / Reduced levels of pulmonary surfactant in COVID-19 ARDS. In: Scientific Reports. 2022 ; Vol. 12, No. 1. pp. 1-5.

Bibtex

@article{ed47831962224de3a04da34e524db143,
title = "Reduced levels of pulmonary surfactant in COVID-19 ARDS",
abstract = "To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.",
keywords = "1,2-Dipalmitoylphosphatidylcholine/analysis, Adult, Aged, Bronchoalveolar Lavage Fluid/chemistry, COVID-19/pathology, Case-Control Studies, Female, Humans, Male, Middle Aged, Principal Component Analysis, Pulmonary Surfactants/analysis, SARS-CoV-2/isolation & purification, Severity of Illness Index, Spectrophotometry, Infrared/methods",
author = "Peter Schousboe and Andreas Ronit and Nielsen, {Henning B} and Thomas Benfield and Lothar Wiese and Nikolaos Scoutaris and Henrik Verder and Berg, {Ronan M G} and Povl Verder and Plovsing, {Ronni R}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = mar,
day = "8",
doi = "10.1038/s41598-022-07944-4",
language = "English",
volume = "12",
pages = "1--5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Reduced levels of pulmonary surfactant in COVID-19 ARDS

AU - Schousboe, Peter

AU - Ronit, Andreas

AU - Nielsen, Henning B

AU - Benfield, Thomas

AU - Wiese, Lothar

AU - Scoutaris, Nikolaos

AU - Verder, Henrik

AU - Berg, Ronan M G

AU - Verder, Povl

AU - Plovsing, Ronni R

N1 - © 2022. The Author(s).

PY - 2022/3/8

Y1 - 2022/3/8

N2 - To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

AB - To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

KW - 1,2-Dipalmitoylphosphatidylcholine/analysis

KW - Adult

KW - Aged

KW - Bronchoalveolar Lavage Fluid/chemistry

KW - COVID-19/pathology

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Principal Component Analysis

KW - Pulmonary Surfactants/analysis

KW - SARS-CoV-2/isolation & purification

KW - Severity of Illness Index

KW - Spectrophotometry, Infrared/methods

UR - http://www.scopus.com/inward/record.url?scp=85126080874&partnerID=8YFLogxK

U2 - 10.1038/s41598-022-07944-4

DO - 10.1038/s41598-022-07944-4

M3 - Journal article

C2 - 35260704

VL - 12

SP - 1

EP - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 4040

ER -

ID: 75596291