Abstract
AIMS: To examine a disputed association between the Lewis(a(-)b(-)) phenotype and Type 1 diabetes (T1D).
METHODS: Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.
RESULTS: T1D patients had a lower frequency (4.1%) of Lewis(a(-)b(-)) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(a(-)b(-)) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(a(-)b(-)) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).
CONCLUSIONS: The Lewis(a(-)b(-)) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.
| Original language | English |
|---|---|
| Journal | Diabetic medicine : a journal of the British Diabetic Association |
| Volume | 25 |
| Issue number | 2 |
| Pages (from-to) | 236-8 |
| Number of pages | 3 |
| ISSN | 0742-3071 |
| DOIs | |
| Publication status | Published - Feb 2008 |
Keywords
- Adolescent
- Adult
- Aged
- Antibodies, Bacterial/analysis
- Diabetes Mellitus, Type 1/blood
- Female
- Helicobacter Infections/blood
- Helicobacter pylori/immunology
- Humans
- Immunophenotyping
- Lewis Blood Group Antigens/blood
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Sex Factors