Reduced contralateral hemispheric flow measured by SPECT in cerebellar lesions: crossed cerebral diaschisis

K Sönmezoğlu, B Sperling, T Henriksen, P Tfelt-Hansen, N A Lassen

60 Citations (Scopus)

Abstract

Four patients with clinical signs of cerebellar stroke were studied twice by SPECT using 99mTc-HMPAO as a tracer for cerebral blood flow (CBF). When first scanned 6 to 22 days after onset, all had a region of very low CBF in the symptomatic cerebellar hemisphere, and a mild to moderate CBF reduction (average 10%) in contralateral hemispheric cortex. In all four cases clinical signs of unilateral cerebellar dysfunction were still present when rescanned 1 to 4 months later and the relative CBF decrease in the contralateral cortex of the forebrain also remained. The basal ganglia contralateral to the cerebellar lesion CBF showed variable alterations. A relative CBF decrease was seen in upper part of basal ganglia in all four cases, but it was not a constant phenomenon. A relative CBF increase in both early and late SPECT scans was seen at low levels of neostriatum in two cases. The remote CBF changes in cerebellar stroke seen in the forebrain are probably caused by reduced or abolished cerebellar output. The term "Crossed Cerebral Diaschisis" may be used to describe these CBF changes that would appear to reflect both decreased and increased neuronal activity.
Original languageEnglish
JournalActa Neurologica Scandinavica
Volume87
Issue number4
Pages (from-to)275-80
Number of pages6
ISSN0001-6314
Publication statusPublished - Apr 1993

Keywords

  • Aged
  • Basal Ganglia Diseases
  • Cerebellar Diseases
  • Cerebellum
  • Cerebral Infarction
  • Cerebrovascular Circulation
  • Functional Laterality
  • Humans
  • Male
  • Middle Aged
  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon

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