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Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study

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@article{e80c34e98acf468196c8ed8df6240d2a,
title = "Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study",
abstract = "AIMS: The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.METHODS AND RESULTS: A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.CONCLUSION: Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.",
keywords = "COVID-19, Follow-up, Recovery following COVID-19, Strain echocardiography",
author = "Lassen, {Mats Christian H{\o}jbjerg} and Skaarup, {Kristoffer Grundtvig} and Lind, {Jannie N{\o}rgaard} and Alhakak, {Alia Saed} and Morten Sengel{\o}v and Nielsen, {Anne Bjerg} and Simonsen, {Jakob {\O}ystein} and Johansen, {Niklas Dyrby} and Davidovski, {Filip S{\o}skov} and Jacob Christensen and Henning Bundgaard and Christian Hassager and Reza Jabbari and J{\o}rn Carlsen and Ole Kirk and Lindholm, {Matias Greve} and Kristiansen, {Ole Peter} and Nielsen, {Olav Wendelboe} and Ulrik, {Charlotte Suppli} and Pradeesh Sivapalan and Gunnar Gislason and Rasmus M{\o}gelvang and Jensen, {Gorm Boje} and Peter Schnohr and Peter S{\o}gaard and Solomon, {Scott D} and Kasper Iversen and Jensen, {Jens Ulrik Staehr} and Morten Schou and Tor Biering-S{\o}rensen",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
month = sep,
day = "12",
doi = "10.1002/ejhf.2347",
language = "English",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Recovery of Cardiac Function Following COVID-19 - ECHOVID-19

T2 - A Prospective Longitudinal Cohort Study

AU - Lassen, Mats Christian Højbjerg

AU - Skaarup, Kristoffer Grundtvig

AU - Lind, Jannie Nørgaard

AU - Alhakak, Alia Saed

AU - Sengeløv, Morten

AU - Nielsen, Anne Bjerg

AU - Simonsen, Jakob Øystein

AU - Johansen, Niklas Dyrby

AU - Davidovski, Filip Søskov

AU - Christensen, Jacob

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jørn

AU - Kirk, Ole

AU - Lindholm, Matias Greve

AU - Kristiansen, Ole Peter

AU - Nielsen, Olav Wendelboe

AU - Ulrik, Charlotte Suppli

AU - Sivapalan, Pradeesh

AU - Gislason, Gunnar

AU - Møgelvang, Rasmus

AU - Jensen, Gorm Boje

AU - Schnohr, Peter

AU - Søgaard, Peter

AU - Solomon, Scott D

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Staehr

AU - Schou, Morten

AU - Biering-Sørensen, Tor

N1 - This article is protected by copyright. All rights reserved.

PY - 2021/9/12

Y1 - 2021/9/12

N2 - AIMS: The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.METHODS AND RESULTS: A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.CONCLUSION: Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

AB - AIMS: The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.METHODS AND RESULTS: A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72-92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3-408.0) ng/L vs. 11.7 (5.7-24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.CONCLUSION: Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

KW - COVID-19

KW - Follow-up

KW - Recovery following COVID-19

KW - Strain echocardiography

UR - http://www.scopus.com/inward/record.url?scp=85117115266&partnerID=8YFLogxK

U2 - 10.1002/ejhf.2347

DO - 10.1002/ejhf.2347

M3 - Journal article

C2 - 34514713

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

ER -

ID: 67612004