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Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines

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  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Thurayya Arayssi
  • Manale Harfouche
  • Andrea Darzi
  • Samar Al Emadi
  • Khalid A Alnaqbi
  • Humeira Badsha
  • Farida Al Balushi
  • Carole Dib
  • Bassel Elzorkany
  • Hussein Halabi
  • Mohammed Hammoudeh
  • Wissam Hazer
  • Basel Masri
  • Mira Merashli
  • Mohammed Omair
  • Nelly Salloum
  • Imad Uthman
  • Sumeja Zahirovic
  • Nelly Ziade
  • Raveendhara R Bannuru
  • Timothy McAlindon
  • Mohamed A Nomier
  • Jasvinder A Singh
  • Robin Christensen
  • Peter Tugwell
  • Holger Schünemann
  • Elie A Akl
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Clinical practice guidelines can assist rheumatologists in the proper prescription of newer treatment for rheumatoid arthritis (RA). The objective of this paper is to report on the recommendations for the management of patients with RA in the Eastern Mediterranean region. We adapted the 2015 American College of Rheumatology guidelines in two separate waves. We used the adolopment methodology, and followed the 18 steps of the "Guidelines 2.0" comprehensive checklist for guideline development. For each question, we updated the original guidelines' evidence synthesis, and we developed an Evidence Profile (EP) and an Evidence to Decision (EtD) table. In the first wave, we adoloped eight out of the 15 original questions on early RA. The strength changed for five of these recommendations from strong to conditional, due to one or more of the following factors: cost, impact on health equities, the balance of benefits, and harms and acceptability. In the second wave, we adoloped eight out of the original 44 questions on established RA. The strength changed for two of these recommendations from strong to conditional, in both cases due to cost, impact on health equities, balance of benefits and harms, and acceptability. The panel also developed a good practice recommendation. We successfully adoloped 16 recommendations for the management of early and established RA in the Eastern Mediterranean region. The process proved feasible and sensitive to contextual factors.

Original languageEnglish
JournalClinical Rheumatology
Volume37
Issue number11
Pages (from-to)2947-2959
Number of pages13
ISSN0770-3198
DOIs
Publication statusPublished - Nov 2018

ID: 56057239