Real-world effectiveness and safety of pharmacological thromboprophylaxis in patients undergoing primary total hip and knee arthroplasty: A narrative review

Astrid Blicher Schelde, Astrid Eliasen, Jonas Bjerring Olesen, Thomas Bo Jensen, Espen Jimenez-Solem

Abstract

In this narrative review of the real-world effectiveness and safety of pharmacological thromboprophylaxis following primary total hip and knee arthroplasty, a total of 12 non-interventional observational studies were included. Pharmacological thromboprophylaxis included warfarin, heparins, dabigatran, rivaroxaban, apixaban, acetylsalicylic acid, and fondaparinux. The absolute risks varied across the included studies. These variations can be explained by differences in patient populations, drug exposure, follow-up time, and definition of outcomes, which makes it a challenge to compare the risk estimates. These findings emphasize the need for a large population-based real-world study to provide comparable risk estimates associated with different pharmacological thromboprophylaxis.

Original languageEnglish
Article numberhttps://doi.org/10.1016/j.jor.2019.11.012
JournalJournal of Orthopaedics
Volume19
Pages (from-to)166-173
Number of pages8
ISSN0972-978X
DOIs
Publication statusPublished - 7 Feb 2020

Keywords

  • Drug effectiveness
  • Drug safety
  • Pharmacological thromboprophylaxis
  • Total hip arthroplasty
  • Total knee arthroplasty

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