TY - JOUR
T1 - Rationale and Design of the Hamburg City Health Study
AU - Jagodzinski, Annika
AU - Johansen, Christoffer
AU - Koch-Gromus, Uwe
AU - Aarabi, Ghazal
AU - Adam, Gerhard
AU - Anders, Sven
AU - Augustin, Matthias
AU - der Kellen, Ramona B
AU - Beikler, Thomas
AU - Behrendt, Christian-Alexander
AU - Betz, Christian S
AU - Bokemeyer, Carsten
AU - Borof, Katrin
AU - Briken, Peer
AU - Busch, Chia-Jung
AU - Büchel, Christian
AU - Brassen, Stefanie
AU - Debus, Eike S
AU - Eggers, Larissa
AU - Fiehler, Jens
AU - Gallinat, Jürgen
AU - Gellißen, Simone
AU - Gerloff, Christian
AU - Girdauskas, Evaldas
AU - Gosau, Martin
AU - Graefen, Markus
AU - Härter, Martin
AU - Harth, Volker
AU - Heidemann, Christoph
AU - Heydecke, Guido
AU - Huber, Tobias B
AU - Hussein, Yassin
AU - Kampf, Marvin O
AU - von dem Knesebeck, Olaf
AU - Konnopka, Alexander
AU - König, Hans-Helmut
AU - Kromer, Robert
AU - Kubisch, Christian
AU - Kühn, Simone
AU - Loges, Sonja
AU - Löwe, Bernd
AU - Lund, Gunnar
AU - Meyer, Christian
AU - Nagel, Lina
AU - Nienhaus, Albert
AU - Pantel, Klaus
AU - Petersen, Elina
AU - Püschel, Klaus
AU - Reichenspurner, Hermann
AU - Sauter, Guido
AU - Scherer, Martin
AU - Scherschel, Katharina
AU - Schiffner, Ulrich
AU - Schnabel, Renate B
AU - Schulz, Holger
AU - Smeets, Ralf
AU - Sokalskis, Vladislavs
AU - Spitzer, Martin S
AU - Terschüren, Claudia
AU - Thederan, Imke
AU - Thoma, Tom
AU - Thomalla, Götz
AU - Waschki, Benjamin
AU - Wegscheider, Karl
AU - Wenzel, Jan-Per
AU - Wiese, Susanne
AU - Zyriax, Birgit-Christiane
AU - Zeller, Tanja
AU - Blankenberg, Stefan
PY - 2020/2
Y1 - 2020/2
N2 - The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long-term assessment with the perspective of further examinations after 6 years in a representative European metropolitan population.
AB - The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long-term assessment with the perspective of further examinations after 6 years in a representative European metropolitan population.
KW - Aged
KW - Atrial Fibrillation
KW - Chronic Disease/epidemiology
KW - Cohort Studies
KW - Coronary Artery Disease
KW - Female
KW - Germany/epidemiology
KW - Heart Failure
KW - Humans
KW - Incidence
KW - Life Style
KW - Magnetic Resonance Imaging
KW - Male
KW - Mental Disorders
KW - Middle Aged
KW - Neoplasms
KW - Oral Health
KW - Population Surveillance
KW - Prevalence
KW - Prospective Studies
KW - Proteomics
KW - Quality of Life
KW - Research Design
KW - Risk Factors
KW - Stroke
KW - Surveys and Questionnaires
KW - Sexual dysfunction
KW - Brain MRI
KW - Epidemiology
KW - Ocular diseases
KW - Risk factors
KW - MRI imaging
KW - Psychiatric and psychosomatic disorders
KW - Health service research
KW - Obesity
KW - Cardiac MRI
KW - Resilience
KW - Respiratory diseases
KW - Dementia
KW - Health care
KW - Hamburg
KW - Prevention
KW - Vascular diseases
KW - Lifestyle
KW - Nutrition
KW - Survivorship
KW - Coronary heart disease
KW - Prospective cohort study
KW - Oral health
KW - Cancer
UR - http://www.scopus.com/inward/record.url?scp=85074818742&partnerID=8YFLogxK
U2 - 10.1007/s10654-019-00577-4
DO - 10.1007/s10654-019-00577-4
M3 - Journal article
C2 - 31705407
SN - 0393-2990
VL - 35
SP - 169
EP - 181
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 2
ER -