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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Rare cause of spontaneous haemothorax: mediastinal and distant lymph node metastases from uveal melanoma

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  1. Severe acute hepatitis E infection presenting with acute abdomen and meningoencephalitis

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  2. Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis

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  3. Intracranial entrapment of a haemodialysis catheter guidewire

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  4. Hepatic epitheloid haemangioendothelioma: a rare malignant tumour

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  1. Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer

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  2. Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations

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  3. Improved Progression-Free Long-Term Survival of a Nation-Wide Patient Population with Metastatic Melanoma

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We report a rare case of isolated mediastinal and inferior mediastinal lymph node metastases from choroidal melanoma. The patient was treated for primary choroidal melanoma with local tumour resection and radioactive plaque brachytherapy. Eleven years later, he was diagnosed with metastatic disease. Molecular analysis of the metastatic tumour demonstrated a GNAQ Q209P mutation. There was no evidence of malignant blue naevus or primary melanoma of the central nervous system on physical examination or imaging. The rare modality of clinical presentation highlights the unpredictable nature of metastatic uveal melanoma.

Original languageEnglish
Article numbere231534
JournalBMJ Case Reports
Volume12
Issue number11
ISSN1757-790X
DOIs
Publication statusPublished - 21 Nov 2019

ID: 58521942