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Rapid Postnatal Adaptation of Neurodevelopment in Pigs Born Late Preterm

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  1. Physical Activity and Spatial Memory Are Minimally Affected by Moderate Growth Restriction in Preterm Piglets

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health

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  2. Plasma Metabolomics to Evaluate Progression of Necrotising Enterocolitis in Preterm Pigs

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  3. Supplemental Insulin-Like Growth Factor-1 and Necrotizing Enterocolitis in Preterm Pigs

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  4. Radiographic Imaging to Evaluate Food Passage Rate in Preterm Piglets as a Model for Preterm Infants

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  5. Gut transit time, using radiological contrast imaging, to predict early signs of necrotizing enterocolitis

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Preterm birth interrupts intrauterine brain growth and maturation and may induce a delay in postnatal neurodevelopment. Such developmental delays can result from the reduced fetal age at birth, together with the clinical compli-cations of preterm birth (e.g., hypoxia, ischemia, and inflammation). We hypothesized that late preterm birth, inducing only mild clinical complications, has minimal effects on brain-related outcomes such as motor function and behavior. Using the pig as a model for late preterm infants, piglets were cesarean delivered preterm (90%, 106 days gestation) or at full term, reared by identical procedures, and euthanized for tissue collection at birth or after 11 days (e.g., term-corrected age for preterm pigs). Clinical variables and both structural and functional brain endpoints were assessed. The preterm pigs were slow to get on their feet, gained less weight (-30%), and had a higher cerebral hydration level and blood-to-cerebrospinal fluid permeability than the term pigs. At term-corrected age (11 days), the absolute weight of the brain and the weights of its regions were similar between 11-day-old preterm and newborn term pigs, and both were lower than in 11-day-old term pigs. Postnatally, physical activity and movements in an open field were similar, except that preterm pigs showed a reduced normalized stride length and increased normalized maximum stride height. Perinatal brain growth is closely associated with advancing postconceptional age in pigs, and late preterm birth is initially associated with impaired brain growth and physical activity. Postnatally, neuromuscular functions mature rapidly and become similar to those in term pigs, even before term-corrected age. Neuromuscular functions and behavior may show rapid postnatal adaptation to late preterm birth in both pigs and infants.

Original languageEnglish
JournalDevelopmental Neuroscience
Volume40
Issue number5-6
Pages (from-to)586-600
Number of pages15
ISSN0378-5866
DOIs
Publication statusPublished - 2018

ID: 59291280