Abstract
A multiplex PCR DNA strip assay (Genotype MTBDR) designed to detect rifampin (rpoB) and high-level isoniazid (katG) resistance mutations in Mycobacterium tuberculosis isolates was optimized for clinical specimens. Successful genotypic results were achieved with 36 of 38 (95%) smear-positive respiratory specimens, allowing rapid therapeutic adjustments in transmittable drug-resistant tuberculosis.
| Original language | English |
|---|---|
| Journal | Journal of Clinical Microbiology |
| Volume | 44 |
| Issue number | 7 |
| Pages (from-to) | 2605-8 |
| Number of pages | 4 |
| ISSN | 0095-1137 |
| DOIs | |
| Publication status | Published - Jul 2006 |
| Externally published | Yes |
Keywords
- Antibiotics, Antitubercular
- Antitubercular Agents
- Body Fluids
- Drug Resistance, Bacterial
- Genotype
- Humans
- Isoniazid
- Microbial Sensitivity Tests
- Mycobacterium tuberculosis
- Polymerase Chain Reaction
- Rifampin
- Tuberculosis, Multidrug-Resistant
- Journal Article