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Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8(+) T cells

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study

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  2. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics

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  3. Skin tape stripping: Which layers of the epidermis are removed?

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  1. Highlights in allergic contact dermatitis 2018/2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Skin tape stripping: Which layers of the epidermis are removed?

    Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: Skin-resident memory T (TRM ) cells are associated with immunological memory in the skin. Whether immunological memory responses to allergens in the skin are solely localized to previously allergen-exposed sites or are present globally in the skin is not clear. Furthermore, the mechanisms whereby TRM cells induce rapid recall responses need further investigation.

OBJECTIVES: To study whether contact allergens induce local and/or global memory, and to determine the mechanisms involved in memory responses in the skin.

METHODS: To address these questions, we analysed responses to contact allergens in mice and humans sensitized to 2,4-dinitrofluorobenzene and nickel, respectively.

RESULTS: Challenge responses in both mice and humans were dramatically increased at sites previously exposed to allergens as compared with previously unexposed sites. Importantly, the magnitude of the challenge response correlated with the epidermal accumulation of interleukin (IL)-17A-producing and interferon (IFN)-γ-producing TRM cells. Moreover, IL-17A and IFN-γ enhanced allergen-induced IL-1β production in keratinocytes.

CONCLUSIONS: We show that sensitization with contact allergens induces a strong, long-lasting local memory and a weaker, temporary global immunological memory response to the allergen that is mediated by IL-17A-producing and IFN-γ-producing CD8(+) TRM cells.

Original languageEnglish
JournalContact Dermatitis
Volume76
Issue number4
Pages (from-to)218-227
ISSN0105-1873
DOIs
Publication statusPublished - Apr 2017

ID: 49271683