Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Randomized Controlled Trial of the Hemodynamic Effects of Empagliflozin in Patients With Type 2 Diabetes at High Cardiovascular Risk: The SIMPLE Trial

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Glucagon Clearance is Preserved in Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Three decades of heart transplantation: experience and long-term outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence rates of dilated cardiomyopathy in adult first-degree relatives versus matched controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Early Coronary Atherosclerosis in Women With Previous Preeclampsia

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Treatment with the sodium-glucose cotransporter 2 inhibitor (SGLT-2i) empagliflozin significantly reduces cardiovascular events in patients with type 2 diabetes (T2D); however, the mechanisms behind the reduction in cardiovascular (CV) events are unknown. We investigated whether SGLT-2i treatment affected central hemodynamics during rest and exercise in 34 patients with diabetes in this investigator-initiated, randomized, placebo-controlled, double-blinded trial. The primary end point was change in pulmonary capillary wedge pressure (PCWP) at a submaximal ergometer workload (25 W) after 13 weeks of SGLT-2i treatment (25 mg once daily) compared with placebo. Secondary end points included changes in resting hemodynamics. Baseline and follow-up hemodynamic assessments were performed at rest, submaximal exercise (25 W), and peak exercise using right heart catheterization. Treatment with empagliflozin for 13 weeks in patients with T2D at high CV risk did not reduce left heart filling pressure more than placebo at submaximal exercise. At rest, we observed that empagliflozin reduced PCWP at a magnitude of clinical significance.

Original languageEnglish
JournalDiabetes
Volume71
Issue number4
Pages (from-to)812-820
Number of pages9
ISSN0012-1797
DOIs
Publication statusPublished - 1 Apr 2022

Bibliographical note

© 2022 by the American Diabetes Association.

ID: 75904736