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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Radioiodine therapy in hyperthyroid disease: poorer outcome in patients with high 24 hours radioiodine uptake

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PURPOSE: To evaluate the importance of 24 h radioiodine uptake (24 h RIU) for the outcome of radioiodine treatment of hyperthyroidism.

METHODS: Retrospective analysis of 72 patients who underwent radioiodine treatment for toxic goiter at our outpatient clinic [29 diffuse goiters (DG), 30 toxic multinodular goiters (TMG) and 13 toxic adenomas (TA)]. Thyroid status was determined by TSH, fT3 and fT4 levels, and outcome was rendered successful when hyperthyroidism was absent. Relation between low 24 h RIU (below median) or high 24 h RIU (above or equal to median) and outcome was evaluated.

RESULTS: Of patients with DG and low 24 h RIU, 15% remained hyperthyroid, as opposed to 56% of patients with DG and high 24 h RIU (P<0.05). Of patients with TMG and low 24 h RIU, none remained hyperthyroid, as opposed to 44% of patients with TMG and high 24 h RIU (P<0.01). Of patients with TA and low 24 h RIU, none remained hyperthyroid, as opposed to 43% of patients with TA and high 24 h RIU (NS, P = 0.19).

CONCLUSION: In patients with hyperthyroid disease treated with radioiodine the outcome is poorer for patients with high 24 h RIU compared with low 24 h RIU measured prior to treatment when the radioiodine dose is calculated on the basis of 24 h RIU.

Original languageEnglish
JournalClinical Physiology and Functional Imaging
Volume26
Issue number3
Pages (from-to)167-70
Number of pages4
ISSN1475-0961
DOIs
Publication statusPublished - May 2006

    Research areas

  • Dose-Response Relationship, Radiation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperthyroidism/radiotherapy, Iodine Radioisotopes/pharmacokinetics, Male, Middle Aged, Retrospective Studies, Thyroid Function Tests, Thyrotropin/blood, Thyroxine/blood, Treatment Outcome, Triiodothyronine/blood

ID: 55072514