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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Radioguided Surgery for Localization of Nonpalpable Breast Lesions A Mini-Review

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  1. Preparation and administration of I-125 labeled seeds for localization of nonpalpable breast lesions

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  2. Easy and Efficient 111Indium Labeling of Long-Term Stored DTPA Conjugated Protein

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  1. Change in mammographic density across birth cohorts of Dutch breast cancer screening participants

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  2. Mammographic Density and Screening Sensitivity, Breast Cancer Incidence and Associated Risk Factors in Danish Breast Cancer Screening

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  3. Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark

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  4. Very Early Response Evaluation by PET/MR in Patients with Lung Cancer-Timing and Feasibility

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The majority of patients with nonpalpable breast lesions are eligible for breast conserving surgery guided by some kind of lesion localization. The current standard is wire-guided localization (WGL) even though it has several disadvantages, the most important one being the considerable proportion of patients with insufficient resection margin. These patients require a reoperation. New methods in the field of radioguided surgery (RGS) have been developed including radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL). Especially RSL is a very promising technique. Guided by ultrasound a small titanium seed containing typically 1-10 MBq of radioactive iodine-125 is placed in the centre of the nonpalpable breast lesion. During the operation the seed is located with a hand-held gamma probe. To date, only few cohort studies exist on the feasibility of RSL, and the method has only been tested in one randomized trial. The results are either equal to or superior to those obtained with WGL, with regards to achieving free margins and low reoperation rates. Additionally, the RSL technique is less unpleasant for the patient and more flexible regarding preoperative logistics. The seed can be placed a few days before surgery, in contrast to the wire used in WGL, which has to be placed within few hours of surgery. RSL has quickly become popular in surgical and radiological teams that have used the technique and will probably become an important tool for preoperative localization of nonpalpable breast lesions in the near future.

Original languageEnglish
JournalCurrent Radiopharmaceuticals
Volume9
Issue number2
Pages (from-to)114-20
Number of pages7
ISSN1874-4710
Publication statusPublished - 2016

    Research areas

  • Journal Article, Review

ID: 49612629