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Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

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  1. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

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  2. Distinct immune phenotypes in infants developing asthma during childhood

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  3. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

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  4. Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis

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  5. Enhanced detection of circulating tumor DNA by fragment size analysis

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  1. In vitro 4-1BB stimulation promotes expansion of CD8+ tumor-infiltrating lymphocytes from various sarcoma subtypes

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  2. Maintenance of muscle strength following a one-year resistance training program in older adults

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  3. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

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  4. Can Strain Elastography Predict Malignancy of Soft Tissue Tumors in a Tertiary Sarcoma Center?

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  5. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

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The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.

Original languageEnglish
JournalScience translational medicine
Volume8
Issue number346
Pages (from-to)346ra90
ISSN1946-6234
DOIs
Publication statusPublished - 6 Jul 2016

    Research areas

  • Journal Article

ID: 49582052