Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Rac1 in Muscle Is Dispensable for Improved Insulin Action After Exercise in Mice

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Hypophosphatemic Hypovitaminosis D induces Osteomalacia in the adult female rat

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Activin A determines steroid levels and composition in the fetal testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Chemical UV Filters Mimic the Effect of Progesterone on Ca(2+) Signaling in Human Sperm Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Molecular indicators of denervation in aging human skeletal muscle

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Lykke Sylow
  • Lisbeth L V Møller
  • Gommaar D'Hulst
  • Peter Schjerling
  • Thomas E Jensen
  • Erik A Richter
View graph of relations

Exercise has a potent insulin-sensitivity enhancing effect on skeletal muscle, but the intracellular mechanisms that mediate this effect are not well understood. In muscle, Ras-related C3 botulinum toxin substrate 1 (Rac1) regulates both insulin- and contraction-stimulated glucose transport and is dysregulated in insulin resistant muscle. However, whether Rac1 is involved in mediating enhanced insulin sensitivity after an acute bout of exercise is unresolved. To address this question, we investigated after exercise whole-body (insulin tolerance test) as well as muscle (insulin-stimulated 2-deoxyglucose transport in isolated soleus muscle) insulin sensitivity in inducible muscle-specific Rac1 knockout (mKO) and wild-type (WT) littermate mice. Previous exercise enhanced whole-body insulin sensitivity by 40% in WT mice and rescued the insulin intolerance in Rac1 mKO mice by improving whole-body insulin sensitivity by 230%. In agreement, previous exercise significantly improved insulin sensitivity by 20% in WT and by 40% in Rac1 mKO soleus muscles. These findings suggest that muscle Rac1 is dispensable for the insulin sensitizing effect of exercise. Moreover, insulin resistance in Rac1 mKO mice can be completely normalized by previous exercise explaining why insulin resistant patients can increase insulin action with exercise despite dysfunctional Rac1 activity in muscle.

Original languageEnglish
JournalEndocrinology
Volume157
Issue number8
Pages (from-to)3009-15
Number of pages7
ISSN0013-7227
DOIs
Publication statusPublished - Aug 2016

    Research areas

  • Journal Article

ID: 49639644