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Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens

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  1. Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight

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  2. Injury-mediated decrease in locomotor performance increases predation risk in schooling fish

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  3. Identifying serotonergic mechanisms underlying the corticolimbic response to threat in humans

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  1. The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

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  2. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

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  3. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

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  4. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

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Conventional antibiotics target the growth and the basal life processes of bacteria leading to growth arrest and cell death. The selective force that is inherently linked to this mode of action eventually selects out antibiotic-resistant variants. The most obvious alternative to antibiotic-mediated killing or growth inhibition would be to attenuate the bacteria with respect to pathogenicity. The realization that Pseudomonas aeruginosa, and a number of other pathogens, controls much of their virulence arsenal by means of extracellular signal molecules in a process denoted quorum sensing (QS) gave rise to a new 'drug target rush'. Recently, QS has been shown to be involved in the development of tolerance to various antimicrobial treatments and immune modulation. The regulation of virulence via QS confers a strategic advantage over host defences. Consequently, a drug capable of blocking QS is likely to increase the susceptibility of the infecting organism to host defences and its clearance from the host. The use of QS signal blockers to attenuate bacterial pathogenicity, rather than bacterial growth, is therefore highly attractive, particularly with respect to the emergence of multi-antibiotic resistant bacteria.
Original languageEnglish
JournalRoyal Society of London. Philosophical Transactions. Biological Sciences
Volume362
Issue number1483
Pages (from-to)1213-22
Number of pages10
ISSN0962-8436
DOIs
Publication statusPublished - 29 Jul 2007

    Research areas

  • 4-Butyrolactone, Anti-Bacterial Agents, Biofilms, Cystic Fibrosis, Humans, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing, Virulence

ID: 32731800