Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Quantitative sensory testing in classical trigeminal neuralgia-a blinded study in patients with and without concomitant persistent pain

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Intradural artery dilation during experimentally induced migraine attacks

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Experimental evidence of a functional relationship within the brainstem trigeminocervical complex in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Mechanistic pain profiling in young adolescents with patellofemoral pain before and after treatment: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects

    Research output: Contribution to journalReviewResearchpeer-review

  2. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The chronobiology of migraine: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  4. Reply: The role of neurovascular contact in patients with multiple sclerosis

    Research output: Contribution to journalLetterResearchpeer-review

  5. Health-related quality of life in tension-type headache: a population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The diagnostic criteria of the third International Classification of Headache Disorders state that there should be no neurological deficits in patients with classical trigeminal neuralgia (TN) at clinical examination. However, studies demonstrating sensory abnormalities at bedside examination in TN patients have questioned this. Our aim was to examine whether TN patients without sensory abnormalities at neurological examination have sensory abnormalities at quantitative sensory testing (QST) and whether there were any QST differences between TN with and without concomitant persistent pain. Thirty-six TN patients were investigated with the standardized QST protocol by the German Research Network on Neuropathic Pain. The investigators were blinded to presence of concomitant persistent pain and symptomatic side. Based on comparison to the German Research Network on Neuropathic Pain controls, z scores were calculated to process frequency analyses and Z-profiles. We found increased mechanical detection threshold on the symptomatic side (47.2% vs 0%, P = 0.008), asymptomatic side (33.3% vs 0%, P = 0.011), and hand (36% vs 0%, P < 0.001) in TN compared with controls. The Z-profiles demonstrated increased mechanical detection threshold on the symptomatic side compared with the asymptomatic side (-2.980 vs -2.166, P = 0.040). Thermal and mechanical hyperalgesia was detected bilaterally in the face and the hand. Trigeminal neuralgia patients with concomitant persistent pain tended to have higher mean z score values compared to TN with purely paroxysmal pain indicative of decreased detection thresholds. Trigeminal neuralgia patients with no sensory abnormalities at neurological examination had generalized subclinical hypoesthesia, which was more pronounced on the symptomatic side, and thermal and mechanical hyperalgesia. This could indicate pain-induced hypoesthesia and sensitization induced by central mechanisms.

Original languageEnglish
JournalPain
Volume157
Issue number7
Pages (from-to)1407-14
Number of pages8
ISSN0304-3959
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • Journal Article

ID: 49300869