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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Quantitative liver functions after administration of allyl alcohol to rats

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  1. EXPERIMENTAL ARGYROSIS

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  2. MERCURY ACCUMULATION IN THE ANTERIOR PITUITARY AFTER EXPOSURE TO MERCURIC CHLORIDE

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  3. Selenium accumulation in the oocyte after exposure to sodium selenite

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  4. Kinetic models for plasma disappearance of insulin in normal subjects

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  5. Vasoactive intestinal polypeptide (VIP) and peripheral vasodilation

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In rats a single dose of allyl alcohol (100 microliter per kg body weight) was given to produce periportal liver damage. Prothrombin index was reduced to a minimum after 12 hours and reestablished after 24 hours. The galactose elimination capacity was not changed. Hepatic glutathione content was unchanged for the first 24 hours but was then elevated twofold. Microsomal p-nitro-anisole demethylation showed a slight initial increase and a subsequent reduction. The pattern of these changes is similar to that seen after centrilobular liver damage from acetaminophen overdose (Poulsen et al. 1981 a; Poulsen et al., unpublished results), with the exception that the latter causes glutathione depletion. This indicates that in chemical liver damage ribosomal function, e.g. protein synthesis and drug hydroxylation, is more vulnerable than cytosolic phosphorylation of carbohydrate.

Original languageEnglish
JournalActa Pharmacologica et Toxicologica
Volume54
Issue number2
Pages (from-to)120-3
Number of pages4
ISSN0001-6683
DOIs
Publication statusPublished - Feb 1984

    Research areas

  • 1-Propanol/toxicity, Acetaminophen/toxicity, Acrolein/metabolism, Animals, Anisoles/metabolism, Chemical and Drug Induced Liver Injury/physiopathology, Female, Galactose/metabolism, Glutathione/metabolism, Liver Function Tests, Propanols, Prothrombin Time, Rats, Rats, Inbred Strains, Time Factors

ID: 68409275