Quantitative liver function and morphology after paracetamol administration to rats

The functional status of the liver after paracetamol administration to rats was dissociated with regard to cytosolic and microsomal functions. The cytosolic function, measured as galactose elimination capacity, was unchanged even after high doses of paracetamol. The microsomal function, measured as the prothrombin time, was reversibly decreased to a minimum 12 h after paracetamol administration and showed dose dependence. The structural changes of the liver cells were centrilobular necroses and dilatation of the endoplasmic reticulum. They were most marked 36 h after paracetamol and were not correlated to the functional impairment. We conclude that during acute paracetamol induced liver damage to rats different functions of the liver are unequally influenced and that the structural changes occur later than the functional ones. The paracetamol intoxicated rat is a promising model for further investigation of dissociation of subcellular functions during acute liver damage.