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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors

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  1. Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

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  2. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI

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  3. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

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  4. Comparison of prospective head motion correction with NMR field probes and an optical tracking system

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  5. Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

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  1. Functional-structural assessment of the optic pathways in patients with optic neuritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diagnostic added value of electrical source imaging in presurgical evaluation of patients with epilepsy: A prospective study

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  3. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

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  4. Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods

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  5. Klinisk Neurologi og Neurokirurgi

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In this study quantitation of the degree of deficiency of the blood-brain barrier (BBB) in patients with multiple sclerosis or brain tumors, by using MRI, is shown to be possible. As a measure of permeability of the BBB to Gadolinium-DTPA (Gd-DTPA) the flux per unit of distribution volume per unit of brain mass was used. This quantity was found by introducing the longitudinal relaxation rate (R1) as a measure of concentration of Gd-DTPA in the brain tissue in the mathematical model for the transcapillary transport over the BBB. High accordance between the observed data points and the model was found, and the results were comparable to results obtained from similar studies using positron emission tomography. The improved possibility of quantitating the defect of the BBB by MRI may give new information about pathogenesis or etiology, and leads to improved methods in monitoring the efficacy of treatments in intracranial diseases.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume16
Issue number1
Pages (from-to)117-31
Number of pages14
ISSN0740-3194
Publication statusPublished - 1990

    Research areas

  • Blood-Brain Barrier, Brain, Brain Neoplasms, Contrast Media, Gadolinium, Gadolinium DTPA, Humans, Image Enhancement, Magnetic Resonance Imaging, Models, Biological, Models, Chemical, Models, Structural, Multiple Sclerosis, Organometallic Compounds, Pentetic Acid

ID: 32543362