QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting

Michala V Rose; Godfather Kimaro; Thomas N Nissen; Inge Kroidl; Michael Hoelscher; Ib C Bygbjerg; Sayoki G Mfinanga; Pernille Ravn

doi:10.1371/journal.pone.0037851

QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting

Michala V Rose, Godfather Kimaro, Thomas N Nissen, Inge Kroidl, Michael Hoelscher, Ib C Bygbjerg, Sayoki G Mfinanga, Pernille Ravn

39 Citations (Scopus)

Abstract

To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania.

Original language	English
Journal	P L o S One
Volume	7
Issue number	7
Pages (from-to)	e37851
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0037851
Publication status	Published - 2012

Keywords

Acute Disease
Adolescent
Adult
Age Factors
Child
Child, Preschool
Coinfection
Female
HIV
HIV Infections
Humans
Immunocompromised Host
Infant
Interferon-gamma
Male
Mycobacterium tuberculosis
Reagent Kits, Diagnostic
Sensitivity and Specificity
Survival Rate
Tanzania
Tuberculin Test
Tuberculosis, Pulmonary

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10.1371/journal.pone.0037851

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title = "QuantiFERON{\textregistered}-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting",

abstract = "To determine whether QuantiFERON{\textregistered}-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania.",

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author = "Rose, {Michala V} and Godfather Kimaro and Nissen, {Thomas N} and Inge Kroidl and Michael Hoelscher and Bygbjerg, {Ib C} and Mfinanga, {Sayoki G} and Pernille Ravn",

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doi = "10.1371/journal.pone.0037851",

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volume = "7",

pages = "e37851",

journal = "P L o S One",

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T1 - QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting

AU - Rose, Michala V

AU - Kimaro, Godfather

AU - Nissen, Thomas N

AU - Kroidl, Inge

AU - Hoelscher, Michael

AU - Bygbjerg, Ib C

AU - Mfinanga, Sayoki G

AU - Ravn, Pernille

PY - 2012

Y1 - 2012

N2 - To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania.

AB - To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Child

KW - Child, Preschool

KW - Coinfection

KW - Female

KW - HIV

KW - HIV Infections

KW - Humans

KW - Immunocompromised Host

KW - Infant

KW - Interferon-gamma

KW - Male

KW - Mycobacterium tuberculosis

KW - Reagent Kits, Diagnostic

KW - Sensitivity and Specificity

KW - Survival Rate

KW - Tanzania

KW - Tuberculin Test

KW - Tuberculosis, Pulmonary

U2 - 10.1371/journal.pone.0037851

DO - 10.1371/journal.pone.0037851

M3 - Journal article

C2 - 22808002

SN - 1932-6203

VL - 7

SP - e37851

JO - P L o S One

JF - P L o S One

IS - 7

ER -

QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting

Abstract

Keywords

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