Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study

P B Jeppesen; M Pertkiewicz; A Forbes; L Pironi; S M Gabe; F Joly; B Messing; S Loth; N N Youssef; H Heinze; P Berghöfer

doi:10.1016/j.clnu.2013.03.016

Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study

P B Jeppesen, M Pertkiewicz, A Forbes, L Pironi, S M Gabe, F Joly, B Messing, S Loth, N N Youssef, H Heinze, P Berghöfer

81 Citations (Scopus)

Abstract

Short bowel syndrome (SBS)-intestinal failure (IF) patients have impaired quality of life (QoL) and suffer from the burden of malabsorption and parenteral support (PS). A phase III study demonstrated that treatment with teduglutide, a glucagon-like peptide 2 analogue, reduces PS volumes by 32% while maintaining oral fluid intake constant; placebo-treated patients had reduced PS by 21%, but oral fluid intake increased accordingly. As effects of teduglutide on QoL are unknown, they were investigated here.

Original language	English
Journal	Clinical nutrition (Edinburgh, Scotland)
Volume	32
Issue number	5
Pages (from-to)	713-21
Number of pages	9
ISSN	0261-5614
DOIs	https://doi.org/10.1016/j.clnu.2013.03.016
Publication status	Published - Oct 2013

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Jeppesen, P. B., Pertkiewicz, M., Forbes, A., Pironi, L., Gabe, S. M., Joly, F., Messing, B., Loth, S., Youssef, N. N., Heinze, H., & Berghöfer, P. (2013). Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study. Clinical nutrition (Edinburgh, Scotland), 32(5), 713-21. https://doi.org/10.1016/j.clnu.2013.03.016

Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study. / Jeppesen, P B; Pertkiewicz, M; Forbes, A et al.
In: Clinical nutrition (Edinburgh, Scotland), Vol. 32, No. 5, 10.2013, p. 713-21.

Research output: Contribution to journal › Journal article › Research › peer-review

Jeppesen, PB, Pertkiewicz, M, Forbes, A, Pironi, L, Gabe, SM, Joly, F, Messing, B, Loth, S, Youssef, NN, Heinze, H & Berghöfer, P 2013, 'Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study', Clinical nutrition (Edinburgh, Scotland), vol. 32, no. 5, pp. 713-21. https://doi.org/10.1016/j.clnu.2013.03.016

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abstract = "Short bowel syndrome (SBS)-intestinal failure (IF) patients have impaired quality of life (QoL) and suffer from the burden of malabsorption and parenteral support (PS). A phase III study demonstrated that treatment with teduglutide, a glucagon-like peptide 2 analogue, reduces PS volumes by 32% while maintaining oral fluid intake constant; placebo-treated patients had reduced PS by 21%, but oral fluid intake increased accordingly. As effects of teduglutide on QoL are unknown, they were investigated here.",

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AU - Gabe, S M

AU - Joly, F

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Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study

Abstract

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