Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism

Dan Yaniv; Igor Vainer; Ido Amir; Eyal Robenshtok; Dania Hirsch; Torquil Watt; Ohad Hilly; Yotam Shkedy; Thomas Shpitzer; Gideon Bachar; Raphael Feinmesser; Aviram Mizrachi

doi:10.1002/jso.26983

Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism

Dan Yaniv^*, Igor Vainer, Ido Amir, Eyal Robenshtok, Dania Hirsch, Torquil Watt, Ohad Hilly, Yotam Shkedy, Thomas Shpitzer, Gideon Bachar, Raphael Feinmesser, Aviram Mizrachi

^*Corresponding author for this work

37 Citations (Scopus)

Abstract

OBJECTIVE: The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy.

STUDY DESIGN: Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery.

SETTING: Tertiary medical center.

METHODS: Thyroid specific QOL questionnaire analysis.

RESULTS: A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4.

CONCLUSIONS: Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.

Original language	English
Journal	Journal of Surgical Oncology
Volume	126
Issue number	4
Pages (from-to)	640-648
Number of pages	9
ISSN	0022-4790
DOIs	https://doi.org/10.1002/jso.26983
Publication status	Published - 15 Sept 2022

Keywords

hypothyroidism
PRO
QOL
thyroidectomy
TSH

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10.1002/jso.26983

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title = "Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism",

abstract = "OBJECTIVE: The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy.STUDY DESIGN: Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery.SETTING: Tertiary medical center.METHODS: Thyroid specific QOL questionnaire analysis.RESULTS: A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4.CONCLUSIONS: Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.",

keywords = "hypothyroidism, PRO, QOL, thyroidectomy, TSH",

author = "Dan Yaniv and Igor Vainer and Ido Amir and Eyal Robenshtok and Dania Hirsch and Torquil Watt and Ohad Hilly and Yotam Shkedy and Thomas Shpitzer and Gideon Bachar and Raphael Feinmesser and Aviram Mizrachi",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.",

year = "2022",

month = sep,

day = "15",

doi = "10.1002/jso.26983",

language = "English",

volume = "126",

pages = "640--648",

journal = "Journal of Surgical Oncology",

issn = "0022-4790",

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TY - JOUR

T1 - Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism

AU - Yaniv, Dan

AU - Vainer, Igor

AU - Amir, Ido

AU - Robenshtok, Eyal

AU - Hirsch, Dania

AU - Watt, Torquil

AU - Hilly, Ohad

AU - Shkedy, Yotam

AU - Shpitzer, Thomas

AU - Bachar, Gideon

AU - Feinmesser, Raphael

AU - Mizrachi, Aviram

PY - 2022/9/15

Y1 - 2022/9/15

N2 - OBJECTIVE: The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy.STUDY DESIGN: Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery.SETTING: Tertiary medical center.METHODS: Thyroid specific QOL questionnaire analysis.RESULTS: A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4.CONCLUSIONS: Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.

AB - OBJECTIVE: The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy.STUDY DESIGN: Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery.SETTING: Tertiary medical center.METHODS: Thyroid specific QOL questionnaire analysis.RESULTS: A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4.CONCLUSIONS: Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.

KW - hypothyroidism

KW - PRO

KW - QOL

KW - thyroidectomy

KW - TSH

UR - https://www.scopus.com/pages/publications/85131569169

U2 - 10.1002/jso.26983

DO - 10.1002/jso.26983

M3 - Journal article

C2 - 35689620

AN - SCOPUS:85131569169

SN - 0022-4790

VL - 126

SP - 640

EP - 648

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 4

ER -

Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism

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