Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Quality of life and the associated risk of all-cause mortality in nonischemic heart failure

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Early diastolic strain rate in relation to long term prognosis following isolated coronary artery bypass grafting

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The impact of peripheral artery disease on major adverse cardiovascular events following myocardial infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment elevation myocardial infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Computational simulation models to test bioprosthetic aortic valves: A valuable alternative or addition to bench testing?

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Aortic angle distribution and predictors of horizontal aorta in patients undergoing transcatheter aortic valve replacement

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Return to work after COVID-19 infection - A Danish nationwide registry study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ticagrelor and the risk of Staphylococcus aureus bacteraemia and other infections

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: To examine the association between health-related quality of life (HRQoL) and mortality in patients with heart failure (HF).

BACKGROUND: The potential association of HRQoL and mortality in patients with HF is unclear. We investigated this association in The Danish Study to Assess the Efficacy of Implantable Cardioverter Defibrillators (ICD) in Patients with Non-ischemic Systolic Heart Failure on Mortality (DANISH).

METHODS: In DANISH, a total of 1116 patients with non-ischemic systolic HF on guideline-recommended therapy were randomized to ICD therapy or usual clinical care. HRQoL was assessed at randomization using the disease-specific Minnesota Living with Heart Failure Questionnaire (MLHFQ, 0-105, high score indicating worse HRQoL). Multivariable Cox proportional hazard models were used to compare hazard ratios (HR) for all-cause mortality according to MLHFQ above or below 45, as recommended by a recent meta-analysis, to identify patients with poor HRQoL.

RESULTS: HRQoL was completed by 935 (84%) patients at baseline with a median follow-up of 67 months (IQR 47-83). Patients with poor HRQoL (MLHFQ score > 45, median 60 (IQR 53-71),n = 350) had a higher incidence of all-cause mortality than patients with moderate/good HRQoL (MLHFQ ≤45, median 23 (IQR 13-33), n = 585), respectively 26% vs. 18% with an unadjusted HR of 1.57 (95% CI 1.19-2.08, p = .002), and an adjusted HR of 1.39 (95% CI 1.01-1.91, p = .04).

CONCLUSION: Poor HRQoL was associated with an increased risk of all-cause mortality after adjustment for traditional risk factors.

CLINICAL TRIAL REGISTRATION: https: //clinicaltrials.gov/ct2/show/NCT00542945(DANISH).

Original languageEnglish
JournalInternational Journal of Cardiology
Volume305
Pages (from-to)92-98
Number of pages7
ISSN0167-5273
DOIs
Publication statusPublished - 15 Apr 2020

    Research areas

  • All-cause mortality, Health-related quality of life, Heart failure

ID: 59422995