Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

S Schippling; Lj Balk; F Costello; Peter Alexander Albrecht; L Balcer; Pa Calabresi; Jette Lautrup Battistini Frederiksen; E Frohman; Aj Green; A Klistorner; O Outteryck; F Paul; Gt Plant; G Traber; P Vermersch; P Villoslada; S Wolf; A Petzold

doi:10.1177/1352458514538110

Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

S Schippling, Lj Balk, F Costello, Peter Alexander Albrecht, L Balcer, Pa Calabresi, Jette Lautrup Battistini Frederiksen, E Frohman, Aj Green, A Klistorner, O Outteryck, F Paul, Gt Plant, G Traber, P Vermersch, P Villoslada, S Wolf, A Petzold

Neurology, Department of

189 Citations (Scopus)

Abstract

BACKGROUND: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research.

OBJECTIVE: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials.

METHODS: A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place.

RESULTS: The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed.

CONCLUSION: Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.

Original language	English
Journal	Multiple sclerosis
Volume	21
Issue number	2
Pages (from-to)	163-70
Number of pages	8
ISSN	1352-4585
DOIs	https://doi.org/10.1177/1352458514538110
Publication status	Published - Feb 2015

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Schippling, S., Balk, L., Costello, F., Albrecht, P. A., Balcer, L., Calabresi, P., Frederiksen, J. L. B., Frohman, E., Green, A., Klistorner, A., Outteryck, O., Paul, F., Plant, G., Traber, G., Vermersch, P., Villoslada, P., Wolf, S., & Petzold, A. (2015). Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria. Multiple sclerosis, 21(2), 163-70. https://doi.org/10.1177/1352458514538110

Schippling, S, Balk, L, Costello, F, Albrecht, PA, Balcer, L, Calabresi, P, Frederiksen, JLB, Frohman, E, Green, A, Klistorner, A, Outteryck, O, Paul, F, Plant, G, Traber, G, Vermersch, P, Villoslada, P, Wolf, S & Petzold, A 2015, 'Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria', Multiple sclerosis, vol. 21, no. 2, pp. 163-70. https://doi.org/10.1177/1352458514538110

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title = "Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria",

abstract = "BACKGROUND: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research.OBJECTIVE: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials.METHODS: A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place.RESULTS: The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed.CONCLUSION: Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.",

author = "S Schippling and Lj Balk and F Costello and Albrecht, {Peter Alexander} and L Balcer and Pa Calabresi and Frederiksen, {Jette Lautrup Battistini} and E Frohman and Aj Green and A Klistorner and O Outteryck and F Paul and Gt Plant and G Traber and P Vermersch and P Villoslada and S Wolf and A Petzold",

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year = "2015",

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doi = "10.1177/1352458514538110",

language = "English",

volume = "21",

pages = "163--70",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

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TY - JOUR

T1 - Quality control for retinal OCT in multiple sclerosis

T2 - validation of the OSCAR-IB criteria

AU - Schippling, S

AU - Balk, Lj

AU - Costello, F

AU - Albrecht, Peter Alexander

AU - Balcer, L

AU - Calabresi, Pa

AU - Frederiksen, Jette Lautrup Battistini

AU - Frohman, E

AU - Green, Aj

AU - Klistorner, A

AU - Outteryck, O

AU - Paul, F

AU - Plant, Gt

AU - Traber, G

AU - Vermersch, P

AU - Villoslada, P

AU - Wolf, S

AU - Petzold, A

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research.OBJECTIVE: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials.METHODS: A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place.RESULTS: The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed.CONCLUSION: Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.

AB - BACKGROUND: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research.OBJECTIVE: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials.METHODS: A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place.RESULTS: The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed.CONCLUSION: Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.

U2 - 10.1177/1352458514538110

DO - 10.1177/1352458514538110

M3 - Journal article

C2 - 24948688

VL - 21

SP - 163

EP - 170

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 2

ER -

Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

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