Quality assessment of a placental perfusion protocol

Line Mathiesen, Tina Mose, Thit Juul Mørck, Jeanette Kolstrup Søgaard Nielsen, Leif Kofoed Nielsen, Lisa Leth Maroun, Morten Hanefeld Dziegiel, Lise Grupe Larsen, Lisbeth Ehlert Knudsen

101 Citations (Scopus)

Abstract

Validation of in vitro test systems using the modular approach with steps addressing reliability and relevance is an important aim when developing in vitro tests in e.g. reproductive toxicology. The ex vivo human placental perfusion system may be used for such validation, here presenting the placental perfusion model in Copenhagen including control substances. The positive control substance antipyrine shows no difference in transport regardless of perfusion media used or of terms of delivery (n=59, p
Original languageEnglish
JournalReproductive toxicology (Elmsford, N.Y.)
Volume30
Issue number1
Pages (from-to)138-46
Number of pages9
DOIs
Publication statusPublished - 1 Aug 2010

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