In-vivo Manganese-Enhanced MRI (MEMRI) studies have shown important potential in rodents for the delineation of cytoarchitectural brain features and of functional details. Ex-vivo MEMRI on the other hand offers the possibility to investigate brain microstructure and function with improved spatial resolution and no motion artefacts. Here, ex-vivo lamb brains were immersed in a highly concentrated MnCl2 solution for a month and revealed interesting cytoarchitectural features already 24 hours after immersion and up to 3 months after the end of immersion on MPRAGE images at 3T. A novel ex-vivo MEMRI approach is proposed, which could benefit MEMRI translation to human studies.
|Publication date||11 May 2022|
|Publication status||Published - 11 May 2022|
|Event||Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting - London, Englnd, UK|
Duration: 7 May 2022 → 12 May 2022
|Conference||Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting|
|Location||London, Englnd, UK|
|Period||07/05/2022 → 12/05/2022|