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Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

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  • Andrea Genazzani
  • Nick Panay
  • Tommaso Simoncini
  • Herman Depypere
  • Alfred Mueck
  • Christian Egarter
  • Nicoletta Biglia
  • Tomas Fait
  • Martin Birkhaeuser
  • Sven O Skouby
  • Mark Brincat
  • Steven Goldstein
  • Xiangyan Ruan
  • Cuauhtémoc Celis-Gonzales
  • Santiago Palacios
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Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

Original languageEnglish
JournalGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Volume36
Issue number3
Pages (from-to)190-196
Number of pages7
ISSN0951-3590
DOIs
Publication statusPublished - Mar 2020

    Research areas

  • Antigens, Plant/therapeutic use, Female, Hot Flashes/drug therapy, Humans, Menopause, Plant Extracts/therapeutic use, Pollen, Premenstrual Syndrome/drug therapy, Vitamin E/therapeutic use

ID: 62405722