Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Pulmonary dysfunction due to combination of extra-pulmonary causes and alveolar damage is present from first the day of hospital admission in the early phase of acute pancreatitis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The cost of endoscopic treatment for walled-off pancreatic necrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The sentinel acute pancreatitis event hypothesis revisited

    Research output: Contribution to journalLetterResearchpeer-review

  3. Evaluation of local instillation of antibiotics in infected walled-off pancreatic necrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Pain in pancreatic ductal adenocarcinoma: A multidisciplinary, International guideline for optimized management

    Research output: Contribution to journalReviewResearchpeer-review

  5. Infection increases mortality in necrotizing pancreatitis: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  1. Colorectal Cancer in Individuals With Familial Adenomatous Polyposis, Based on Analysis of the Danish Polyposis Registry

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Modified Marshall Score Predicts Mortality in Patients With Walled-off Pancreatic Necrosis Treated in an Intensive Care Unit

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The cost of endoscopic treatment for walled-off pancreatic necrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Only few studies have attempted to evaluate the pulmonary function in the early phase of acute pancreatitis (AP), although pulmonary dysfunction is the most frequent complication in the early phase of AP. We aimed to evaluate the changes in pulmonary function tests during the early phase of AP. Methods: Prospective cohort study including 44 patients (52% men; median age 54 years) admitted with first attack of AP and 22 healthy controls. Patients underwent assessments on day 1, 2, 3, 6, and 10 as well as one month after discharge. Pulmonary function tests included the % predicted: forced expiratory volume during the first second (FEV1), forced vital capacity (FVC), total lung capacity (TLC), diffusion lung capacity (DLCO) and the ratio between DLCO and alveolar volume (DLCO/VA). Results: In total, 9% developed severe acute pancreatitis, 7% died, and 14% required treatment at the intensive or semi-intensive care unit. From admission, patients had impaired FEV1, FVC, DLCO, and TLC compared with controls (p < 0.0001 in all analyses). Patients with CRP >150 mg/L had significantly lower lung function tests. One month after discharge, lung function tests improved but patients had lower FEV1 (p = 0.014), FVC (p = 0.022), TLC (p = 0.020), and DLCO (p < 0.001) compared with controls. Conclusion: This study found that patients with AP had evidence of pulmonary impairment from the first day after hospital admission. The impairment lasted several weeks after hospital discharge.

Original languageEnglish
JournalPancreatology
Volume19
Issue number4
Pages (from-to)519-523
Number of pages5
ISSN1424-3903
DOIs
Publication statusPublished - Jun 2019

Bibliographical note

Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.

    Research areas

  • Atelectasis, Diffusion capacity, Gas exchange, Pancreatitis, Pleural effusion, Respiratory dysfunction

ID: 57090915