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Pulmonary arterial enlargement in well-treated persons with HIV

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@article{636f66ba524042b7b7431ba131bc82fa,
title = "Pulmonary arterial enlargement in well-treated persons with HIV",
abstract = "BACKGROUND: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with HIV (PWH) and uninfected controls.METHODS: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of the diameter of the main pulmonary artery at the level of its bifurcation divided by the diameter of the ascending aorta (PA:A)>1.RESULTS: In total, 900 PWH were included and 44 (5{\%}) had PA:A>1. After adjusting for age, sex and BMI, obesity (adjusted odds ratio, aOR: 4.33 [1.76-10.65], p=.001) and intravenous drug use (aOR: 4.90 [1.00-18.46], p=.027) were associated with higher odds of PA:A>1. Pulmonary indices or smoking were not associated with PA:A>1. HIV seropositivity was borderline associated with PA:A>1 (aOR: 1.89 [0.92-3.85], p=.081).CONCLUSIONS: PA:A>1 was common in PWH. Obesity and intravenous drug use were independently associated with PA:A>1, but HIV-related factors were not. HIV serostatus was borderline associated with PA:A>1. Increased awareness may be appropriate in obese PWH and in those with intravenous drug use.",
author = "Knudsen, {Andreas D} and Andreas Ronit and Thomas Kristensen and Thomsen, {Magda Teresa} and Anne-Mette Lebech and Pham, {Michael Huy Cuong} and Per Sigvardsen and K{\"U}hl, {J{\o}rgen Tobias} and Andreas Fuchs and Lars K{\O}ber and Jens Lundgren and J{\o}rgen Vestbo and Kofoed, {Klaus F} and Nielsen, {Susanne D}",
note = "{\circledC} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "6",
day = "19",
doi = "10.1093/infdis/jiaa339",
language = "English",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "University of Chicago Press",

}

RIS

TY - JOUR

T1 - Pulmonary arterial enlargement in well-treated persons with HIV

AU - Knudsen, Andreas D

AU - Ronit, Andreas

AU - Kristensen, Thomas

AU - Thomsen, Magda Teresa

AU - Lebech, Anne-Mette

AU - Pham, Michael Huy Cuong

AU - Sigvardsen, Per

AU - KÜhl, Jørgen Tobias

AU - Fuchs, Andreas

AU - KØber, Lars

AU - Lundgren, Jens

AU - Vestbo, Jørgen

AU - Kofoed, Klaus F

AU - Nielsen, Susanne D

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/6/19

Y1 - 2020/6/19

N2 - BACKGROUND: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with HIV (PWH) and uninfected controls.METHODS: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of the diameter of the main pulmonary artery at the level of its bifurcation divided by the diameter of the ascending aorta (PA:A)>1.RESULTS: In total, 900 PWH were included and 44 (5%) had PA:A>1. After adjusting for age, sex and BMI, obesity (adjusted odds ratio, aOR: 4.33 [1.76-10.65], p=.001) and intravenous drug use (aOR: 4.90 [1.00-18.46], p=.027) were associated with higher odds of PA:A>1. Pulmonary indices or smoking were not associated with PA:A>1. HIV seropositivity was borderline associated with PA:A>1 (aOR: 1.89 [0.92-3.85], p=.081).CONCLUSIONS: PA:A>1 was common in PWH. Obesity and intravenous drug use were independently associated with PA:A>1, but HIV-related factors were not. HIV serostatus was borderline associated with PA:A>1. Increased awareness may be appropriate in obese PWH and in those with intravenous drug use.

AB - BACKGROUND: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with HIV (PWH) and uninfected controls.METHODS: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of the diameter of the main pulmonary artery at the level of its bifurcation divided by the diameter of the ascending aorta (PA:A)>1.RESULTS: In total, 900 PWH were included and 44 (5%) had PA:A>1. After adjusting for age, sex and BMI, obesity (adjusted odds ratio, aOR: 4.33 [1.76-10.65], p=.001) and intravenous drug use (aOR: 4.90 [1.00-18.46], p=.027) were associated with higher odds of PA:A>1. Pulmonary indices or smoking were not associated with PA:A>1. HIV seropositivity was borderline associated with PA:A>1 (aOR: 1.89 [0.92-3.85], p=.081).CONCLUSIONS: PA:A>1 was common in PWH. Obesity and intravenous drug use were independently associated with PA:A>1, but HIV-related factors were not. HIV serostatus was borderline associated with PA:A>1. Increased awareness may be appropriate in obese PWH and in those with intravenous drug use.

U2 - 10.1093/infdis/jiaa339

DO - 10.1093/infdis/jiaa339

M3 - Journal article

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

ER -

ID: 60097395