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Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

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@article{cd413f0786fe4105897cf29090da76a0,
title = "Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action",
abstract = "Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.",
author = "Hagen, {Casper P} and Kaspar S{\o}rensen and Lise Aksglaede and Annette Mouritsen and Mieritz, {Mikkel G} and Jeanette Tinggaard and Christine Wohlfart-Veje and Petersen, {J{\o}rgen Holm} and Main, {Katharina M} and {Rajpert-De Meyts}, Ewa and Kristian Almstrup and Anders Juul",
year = "2014",
doi = "10.1038/srep06412",
language = "English",
volume = "4",
pages = "6412",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

AU - Hagen, Casper P

AU - Sørensen, Kaspar

AU - Aksglaede, Lise

AU - Mouritsen, Annette

AU - Mieritz, Mikkel G

AU - Tinggaard, Jeanette

AU - Wohlfart-Veje, Christine

AU - Petersen, Jørgen Holm

AU - Main, Katharina M

AU - Rajpert-De Meyts, Ewa

AU - Almstrup, Kristian

AU - Juul, Anders

PY - 2014

Y1 - 2014

N2 - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

AB - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

U2 - 10.1038/srep06412

DO - 10.1038/srep06412

M3 - Journal article

VL - 4

SP - 6412

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -

ID: 44557645