Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

Research output: Contribution to journalJournal articleResearchpeer-review

Documents

DOI

  1. Discrete finger sequences are widely represented in human striatum

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Author Correction: Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Validation of the four-miRNA biomarker panel MiCaP for prediction of long-term prostate cancer outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Marked Increase in Incident Gynecomastia: A 20-Year National Registry Study, 1998 to 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

Original languageEnglish
JournalScientific Reports
Volume4
Pages (from-to)6412
ISSN2045-2322
DOIs
Publication statusPublished - 2014

Most downloaded publications

No data available

ID: 44557645