Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

Casper P Hagen; Kaspar Sørensen; Lise Aksglaede; Annette Mouritsen; Mikkel G Mieritz; Jeanette Tinggaard; Christine Wohlfart-Veje; Jørgen Holm Petersen; Katharina M Main; Ewa Rajpert-De Meyts; Kristian Almstrup; Anders Juul

doi:10.1038/srep06412

Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

Casper P Hagen, Kaspar Sørensen, Lise Aksglaede, Annette Mouritsen, Mikkel G Mieritz, Jeanette Tinggaard, Christine Wohlfart-Veje, Jørgen Holm Petersen, Katharina M Main, Ewa Rajpert-De Meyts, Kristian Almstrup, Anders Juul

Department of Growth and Reproduction

35 Citations (Scopus)

83 Downloads (Pure)

Abstract

Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

Original language	English
Journal	Scientific Reports
Volume	4
Pages (from-to)	6412
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep06412
Publication status	Published - 2014

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10.1038/srep06412

Hagen et al 2014 Science Report

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title = "Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action",

abstract = "Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.",

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doi = "10.1038/srep06412",

language = "English",

volume = "4",

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T1 - Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

AU - Hagen, Casper P

AU - Sørensen, Kaspar

AU - Aksglaede, Lise

AU - Mouritsen, Annette

AU - Mieritz, Mikkel G

AU - Tinggaard, Jeanette

AU - Wohlfart-Veje, Christine

AU - Petersen, Jørgen Holm

AU - Main, Katharina M

AU - Rajpert-De Meyts, Ewa

AU - Almstrup, Kristian

AU - Juul, Anders

PY - 2014

Y1 - 2014

N2 - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

AB - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

UR - https://www.scopus.com/pages/publications/84923380662

U2 - 10.1038/srep06412

DO - 10.1038/srep06412

M3 - Journal article

C2 - 25231187

SN - 2045-2322

VL - 4

SP - 6412

JO - Scientific Reports

JF - Scientific Reports

ER -

Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

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