Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Pubertal onset in boys and girls is influenced by pubertal timing of both parents

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Hydroxylated Long-Chain Acylcarnitines are Biomarkers of Mitochondrial Myopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hippocampal volume, cognitive functions, depression, anxiety, and quality of life in patients with Cushing's syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Impaired Fat Oxidation During Exercise in Long-Chain Acyl-CoA Dehydrogenase Deficiency Patients and Effect of IV-Glucose

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Populations, decreasing fertility, and reproductive health

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

CONTEXT: Epidemiological evidence on maternal and paternal heritability of the wide normal variation within pubertal timing is sparse.

OBJECTIVE: We aimed to estimate the impact of parental pubertal timing on onset of puberty in boys and girls.

DESIGN: Annual pubertal examinations of healthy children in a longitudinal cohort study. Information on parental timing of puberty (earlier, comparable to or later compared to peers) and menarche-age was retrieved from questionnaires.

PARTICIPANTS: 672 girls 846 boys.

MAIN OUTCOME MEASURES: Age at onset of pubic hair (PH2+), breasts (B2+) and menarche in girls and PH2+, genital stage (G2+) and testis > 3 ml with orchidometer (Tvol3+) in boys.

RESULTS: In boys, pubertal onset was significantly associated with pubertal timing of both parents. PH2+ and Tvol3+ were earlier: -11.8 months (95% CI: -16.8;-6.8) / -8.9(-12.8;-4.9) and -9.5(-13.9;-5.1)/ -7.1(-10.4;-3.7) if the father/mother respectively had early pubertal development compared to late. In girls, menarche was significantly associated with both parents' pubertal timing: -10.5 months (-15.9;-5.1) / -10.1 (-14.3;-6.0) if father/mother had early pubertal development compared to late. For onset of PH2+and B2+ in girls estimates were -7.0 months (-12.6;-1.4) and -4.1(-10.6; +2.4)/ -6.7(-11.0;-2.5) and -6.7(-11.0;-2.0) for fathers/ mothers, respectively. Maternal age of menarche was significantly associated with onset of all pubertal milestones except PH2+ in girls.

CONCLUSIONS: Maternal as well as paternal pubertal timing were strong determinants of age at pubertal onset in both girls and boys. Age at breast and pubic hair development in girls, which has declined most during recent years, seemed to be least dependent on heritability.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume101
Issue number7
Pages (from-to)2667-2674
ISSN0021-972X
DOIs
Publication statusPublished - 25 Mar 2016

ID: 46427215