Abstract
Background: Schizophrenia and ADHD share a number of attention related symptoms and cognitive impairments. Early onset psychosis may precede a development of schizophrenia and must be distinguished from ADHD. Psychophysiological deficits are studied as endophenotypic markers of psychosis and may add valuable information on how to differentiate premature stages of early onset psychosis from ADHD.
Aim: To characterize psychophysiological deficits in young adolescents with psychosis or ADHD and compare the profiles of impariments between the two groups.
Materials and methods: A cohort of young adolescents (age 12-17 years) with either first episode psychosis or ADHD and age and gender matched healthy controls has been recruited. The assessments include a diagnostic interview, psychopathological ratings and psychophysiological assessment of prepulse inhibiton of the startle reflex (PPI) with high and low intensity prepulse trials, Mismatch Negativity (MMN), Selective Attention (SA) and P50.
Results: Preliminary analyses of 18 patients with psychosis and 12 patients with ADHD showed significantly less PPI in the higher intensity prepulse trials in the psychosis group than in the ADHD group. No significant group difference was found in the lower intensity prepulse trials.
Conclusion: The preliminary results indicate lower levels of PPI in adolescents with early onset psychosis than in young patients with ADHD. If these results hold in the final analyses then this knowledge may contribute to better and early differentiation between early onset psychosis and ADHD.
Aim: To characterize psychophysiological deficits in young adolescents with psychosis or ADHD and compare the profiles of impariments between the two groups.
Materials and methods: A cohort of young adolescents (age 12-17 years) with either first episode psychosis or ADHD and age and gender matched healthy controls has been recruited. The assessments include a diagnostic interview, psychopathological ratings and psychophysiological assessment of prepulse inhibiton of the startle reflex (PPI) with high and low intensity prepulse trials, Mismatch Negativity (MMN), Selective Attention (SA) and P50.
Results: Preliminary analyses of 18 patients with psychosis and 12 patients with ADHD showed significantly less PPI in the higher intensity prepulse trials in the psychosis group than in the ADHD group. No significant group difference was found in the lower intensity prepulse trials.
Conclusion: The preliminary results indicate lower levels of PPI in adolescents with early onset psychosis than in young patients with ADHD. If these results hold in the final analyses then this knowledge may contribute to better and early differentiation between early onset psychosis and ADHD.
| Original language | English |
|---|---|
| Publication date | 8 Oct 2014 |
| Number of pages | 1 |
| Publication status | Published - 8 Oct 2014 |
| Event | Forskningsdag 2014, Glostrup Hospital - Glostrup, Denmark Duration: 8 Oct 2014 → 8 Oct 2014 |
Conference
| Conference | Forskningsdag 2014, Glostrup Hospital |
|---|---|
| Country/Territory | Denmark |
| City | Glostrup |
| Period | 08/10/2014 → 08/10/2014 |