Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Psychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genetic and environmental transactions underlying the association between physical fitness/physical exercise and body composition

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multivariate genetic analysis of brain structure in an extended twin design.

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Psychotic experiences from preadolescence to adolescence: when should we be worried about adolescent risk behaviors?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mental Health Service Use and Psychopharmacological Treatment Following Psychotic Experiences in Preadolescence

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Preschool family irregularity and the development of sleep problems in childhood: a longitudinal study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Arija G Jansen
  • Gwen C Dieleman
  • Philip R Jansen
  • Frank C Verhulst
  • Danielle Posthuma
  • Tinca J C Polderman
View graph of relations

Neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable and influenced by many single nucleotide polymorphisms (SNPs). SNPs can be used to calculate individual polygenic risk scores (PRS) for a disorder. We aim to explore the association between the PRS for ADHD, ASD and for Schizophrenia (SCZ), and ADHD and ASD diagnoses in a clinical child and adolescent population. Based on the most recent genome wide association studies of ADHD, ASD and SCZ, PRS of each disorder were calculated for individuals of a clinical child and adolescent target sample (N = 688) and for adult controls (N = 943). We tested with logistic regression analyses for an association with (1) a single diagnosis of ADHD (N = 280), (2) a single diagnosis of ASD (N = 295), and (3) combining the two diagnoses, thus subjects with either ASD, ADHD or both (N = 688). Our results showed a significant association of the ADHD PRS with ADHD status (OR 1.6, P = 1.39 × 10-07) and with the combined ADHD/ASD status (OR 1.36, P = 1.211 × 10-05), but not with ASD status (OR 1.14, P = 1). No associations for the ASD and SCZ PRS were observed. In sum, the PRS of ADHD is significantly associated with the combined ADHD/ASD status. Yet, this association is primarily driven by ADHD status, suggesting disorder specific genetic effects of the ADHD PRS.

Original languageEnglish
JournalBehavior Genetics
Volume50
Issue number4
Pages (from-to)203-212
Number of pages10
ISSN0001-8244
DOIs
Publication statusPublished - Jul 2020

ID: 58383410