Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Psoriasis and adverse pregnancy outcomes: A nationwide case-control study in 491,274 women in Denmark

Research output: Contribution to journalJournal articlepeer-review

  1. Hand eczema, wet work exposure, and quality of life in health care workers in Denmark during the COVID-19 pandemic

    Research output: Contribution to journalJournal articlepeer-review

  1. Rapid improvement of idiopathic aphthous ulcers with oral roflumilast therapy

    Research output: Contribution to journalLetterpeer-review

View graph of relations

Background: The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in an increased risk of adverse pregnancy outcomes (APOs). Objective: To investigate the association between psoriasis and APOs as well as how the association differs according to psoriasis severity (mild and moderate-to-severe). Methods: This nationwide register-based case-control study collected data from 1973 to 2017. Cases were APOs (spontaneous abortion, ectopic pregnancy [EP], intrauterine fetal death, and stillbirth). Singleton live births were controls. Adjusted logistic regression models were used for statistical analyses. Results: In total, 42,041 (8.56%) APOs and 449,233 (91.44%) controls were included. EP was the only APO that was found to be statistically associated with psoriasis (odds ratio, 1.34; 95% CI, 1.06-1.68). Odds ratio for EP was the highest for women with moderate-to-severe psoriasis (odds ratio, 2.77; 95% CI, 1.13-6.76). The absolute risk of EP was 2.48% higher for women with moderate-to-severe psoriasis compared with women without psoriasis (3.98% vs 1.50%). Limitations: No access to clinical data confirming psoriasis severity. Conclusion: The present study found a significant association between EP and psoriasis (absolute risk of 3.98%). As EP is the leading cause of maternal morbidity and mortality in the first trimester of pregnancy, our findings call for particular care for women of reproductive age with psoriasis.

Original languageEnglish
JournalJAAD International
Volume7
Pages (from-to)146-155
Number of pages10
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 American Academy of Dermatology, Inc.

    Research areas

  • ectopic pregnancy, fetal death, pregnancy, pregnancy outcome, psoriasis, psoriasis severity, spontaneous abortion, stillbirth, women

ID: 79293517