Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

N Høiby; H Krogh Johansen; C Moser; Z Song; O Ciofu; A Kharazmi

doi:10.1016/s1286-4579(00)01349-6

Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

N Høiby, H Krogh Johansen, C Moser, Z Song, O Ciofu, A Kharazmi

Abstract

The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

Original language	English
Journal	Microbes and Infection
Volume	3
Issue number	1
Pages (from-to)	23-35
Number of pages	13
ISSN	1286-4579
DOIs	https://doi.org/10.1016/s1286-4579(00)01349-6
Publication status	Published - Jan 2001
Externally published	Yes

Keywords

Animals
Anti-Bacterial Agents/pharmacology
Biofilms
Chronic Disease
Cystic Fibrosis/immunology
Drug Resistance, Microbial
Endopeptidases/metabolism
Humans
Inflammation/immunology
Lung/microbiology
Neutrophils/metabolism
Pseudomonas Infections/microbiology
Pseudomonas aeruginosa/drug effects

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10.1016/s1286-4579(00)01349-6

Cite this

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title = "Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth",

abstract = "The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.",

keywords = "Animals, Anti-Bacterial Agents/pharmacology, Biofilms, Chronic Disease, Cystic Fibrosis/immunology, Drug Resistance, Microbial, Endopeptidases/metabolism, Humans, Inflammation/immunology, Lung/microbiology, Neutrophils/metabolism, Pseudomonas Infections/microbiology, Pseudomonas aeruginosa/drug effects",

author = "N H{\o}iby and {Krogh Johansen}, H and C Moser and Z Song and O Ciofu and A Kharazmi",

year = "2001",

month = jan,

doi = "10.1016/s1286-4579(00)01349-6",

language = "English",

volume = "3",

pages = "23--35",

journal = "Microbes and Infection",

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TY - JOUR

T1 - Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

AU - Høiby, N

AU - Krogh Johansen, H

AU - Moser, C

AU - Song, Z

AU - Ciofu, O

AU - Kharazmi, A

PY - 2001/1

Y1 - 2001/1

N2 - The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

AB - The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

KW - Animals

KW - Anti-Bacterial Agents/pharmacology

KW - Biofilms

KW - Chronic Disease

KW - Cystic Fibrosis/immunology

KW - Drug Resistance, Microbial

KW - Endopeptidases/metabolism

KW - Humans

KW - Inflammation/immunology

KW - Lung/microbiology

KW - Neutrophils/metabolism

KW - Pseudomonas Infections/microbiology

KW - Pseudomonas aeruginosa/drug effects

U2 - 10.1016/s1286-4579(00)01349-6

DO - 10.1016/s1286-4579(00)01349-6

M3 - Review

C2 - 11226851

SN - 1286-4579

VL - 3

SP - 23

EP - 35

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1

ER -

Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

Abstract

Keywords

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