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Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease

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Harvard

Molvin, J, Jujić, A, Melander, O, Pareek, M, Råstam, L, Lindblad, U, Daka, B, Leósdóttir, M, Nilsson, PM, Olsen, MH & Magnusson, M 2020, 'Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease', ESC Heart Failure, vol. 7, no. 6, pp. 4151-4158. https://doi.org/10.1002/ehf2.13036

APA

Molvin, J., Jujić, A., Melander, O., Pareek, M., Råstam, L., Lindblad, U., Daka, B., Leósdóttir, M., Nilsson, P. M., Olsen, M. H., & Magnusson, M. (2020). Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease. ESC Heart Failure, 7(6), 4151-4158. https://doi.org/10.1002/ehf2.13036

CBE

Molvin J, Jujić A, Melander O, Pareek M, Råstam L, Lindblad U, Daka B, Leósdóttir M, Nilsson PM, Olsen MH, Magnusson M. 2020. Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease. ESC Heart Failure. 7(6):4151-4158. https://doi.org/10.1002/ehf2.13036

MLA

Vancouver

Author

Molvin, John ; Jujić, Amra ; Melander, Olle ; Pareek, Manan ; Råstam, Lennart ; Lindblad, Ulf ; Daka, Bledar ; Leósdóttir, Margrét ; Nilsson, Peter M ; Olsen, Michael H ; Magnusson, Martin. / Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease. In: ESC Heart Failure. 2020 ; Vol. 7, No. 6. pp. 4151-4158.

Bibtex

@article{ba48ccd805ad43028dcc5dfe5e45f03b,
title = "Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease",
abstract = "AIMS: The epidemiological association between diabetes and cardiovascular disease is well established, but the pathophysiological link is complex and multifactorial. We investigated seven proteins, previously linked to incident diabetes mellitus, and their association with cardiovascular disease and mortality.METHODS AND RESULTS: Plasma samples from 1713 individuals from the Swedish population-based Malm{\"o} Preventive Project (mean age 67.4 ± 6.0 years; 29.1% women) were analysed with a proximity extension assay panel. Seven proteins [scavenger receptor cysteine rich type 1 protein M130 (CD163), fatty acid-binding protein 4 (FABP4), plasminogen activator inhibitor 1 (PAI), insulin-like growth factor-binding protein 2 (IGFB2), cathepsin D (CTSD), galectin-4 (GAL4), and paraoxonase-3 (PON3)] previously shown to be associated with incident diabetes were analysed for associations with all-cause mortality (ACM), cardiovascular mortality (CVM), incident coronary events (CEs), and incident heart failure (HF). After exclusion of prevalent cases of respective outcome, proteins that met Bonferroni-corrected significance were analysed in multivariable Cox regression models. Significant associations were identified between five proteins [GAL4 (hazard ratio; 95% confidence interval: 1.17-1.41), CTSD (1.15-1.37), CD163 (1.09-1.30), IGFBP2 (1.05-1.30), and FABP4 (1.04-1.29)] and ACM and four proteins [GAL4 (1.38-1.56), CTSD (1.14-1.43), CD163 (1.09-1.36), and IGFBP2 (1.03-1.35)] with CVM. Three proteins [GAL4 (1.14-1.57), CTSD (1.12-1.50), and FABP4 (1.05-1.55)] were significantly associated with incident CE and two [GAL4 (1.03-1.54) and CTSD (1.01-1.46)] were associated with incident HF after adjusting for traditional risk factors including N-terminal pro-brain natriuretic peptide.CONCLUSIONS: In a general Swedish population, four proteins previously shown to be associated with diabetes were associated with ACM and CVM. Three proteins were associated with incident CE. Finally, GAL4 and CTSD displayed novel associations with incident HF and were the only proteins associated with all outcomes.",
keywords = "Cardiometabolic disease, Cardiovascular disease, Cathepsin D, Diabetes, Galectin-4, Proteomics",
author = "John Molvin and Amra Juji{\'c} and Olle Melander and Manan Pareek and Lennart R{\aa}stam and Ulf Lindblad and Bledar Daka and Margr{\'e}t Le{\'o}sd{\'o}ttir and Nilsson, {Peter M} and Olsen, {Michael H} and Martin Magnusson",
note = "{\textcopyright} 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.",
year = "2020",
month = dec,
doi = "10.1002/ehf2.13036",
language = "English",
volume = "7",
pages = "4151--4158",
journal = "E S C Heart Failure",
issn = "2055-5822",
publisher = "JohnWiley & Sons Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease

AU - Molvin, John

AU - Jujić, Amra

AU - Melander, Olle

AU - Pareek, Manan

AU - Råstam, Lennart

AU - Lindblad, Ulf

AU - Daka, Bledar

AU - Leósdóttir, Margrét

AU - Nilsson, Peter M

AU - Olsen, Michael H

AU - Magnusson, Martin

N1 - © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

PY - 2020/12

Y1 - 2020/12

N2 - AIMS: The epidemiological association between diabetes and cardiovascular disease is well established, but the pathophysiological link is complex and multifactorial. We investigated seven proteins, previously linked to incident diabetes mellitus, and their association with cardiovascular disease and mortality.METHODS AND RESULTS: Plasma samples from 1713 individuals from the Swedish population-based Malmö Preventive Project (mean age 67.4 ± 6.0 years; 29.1% women) were analysed with a proximity extension assay panel. Seven proteins [scavenger receptor cysteine rich type 1 protein M130 (CD163), fatty acid-binding protein 4 (FABP4), plasminogen activator inhibitor 1 (PAI), insulin-like growth factor-binding protein 2 (IGFB2), cathepsin D (CTSD), galectin-4 (GAL4), and paraoxonase-3 (PON3)] previously shown to be associated with incident diabetes were analysed for associations with all-cause mortality (ACM), cardiovascular mortality (CVM), incident coronary events (CEs), and incident heart failure (HF). After exclusion of prevalent cases of respective outcome, proteins that met Bonferroni-corrected significance were analysed in multivariable Cox regression models. Significant associations were identified between five proteins [GAL4 (hazard ratio; 95% confidence interval: 1.17-1.41), CTSD (1.15-1.37), CD163 (1.09-1.30), IGFBP2 (1.05-1.30), and FABP4 (1.04-1.29)] and ACM and four proteins [GAL4 (1.38-1.56), CTSD (1.14-1.43), CD163 (1.09-1.36), and IGFBP2 (1.03-1.35)] with CVM. Three proteins [GAL4 (1.14-1.57), CTSD (1.12-1.50), and FABP4 (1.05-1.55)] were significantly associated with incident CE and two [GAL4 (1.03-1.54) and CTSD (1.01-1.46)] were associated with incident HF after adjusting for traditional risk factors including N-terminal pro-brain natriuretic peptide.CONCLUSIONS: In a general Swedish population, four proteins previously shown to be associated with diabetes were associated with ACM and CVM. Three proteins were associated with incident CE. Finally, GAL4 and CTSD displayed novel associations with incident HF and were the only proteins associated with all outcomes.

AB - AIMS: The epidemiological association between diabetes and cardiovascular disease is well established, but the pathophysiological link is complex and multifactorial. We investigated seven proteins, previously linked to incident diabetes mellitus, and their association with cardiovascular disease and mortality.METHODS AND RESULTS: Plasma samples from 1713 individuals from the Swedish population-based Malmö Preventive Project (mean age 67.4 ± 6.0 years; 29.1% women) were analysed with a proximity extension assay panel. Seven proteins [scavenger receptor cysteine rich type 1 protein M130 (CD163), fatty acid-binding protein 4 (FABP4), plasminogen activator inhibitor 1 (PAI), insulin-like growth factor-binding protein 2 (IGFB2), cathepsin D (CTSD), galectin-4 (GAL4), and paraoxonase-3 (PON3)] previously shown to be associated with incident diabetes were analysed for associations with all-cause mortality (ACM), cardiovascular mortality (CVM), incident coronary events (CEs), and incident heart failure (HF). After exclusion of prevalent cases of respective outcome, proteins that met Bonferroni-corrected significance were analysed in multivariable Cox regression models. Significant associations were identified between five proteins [GAL4 (hazard ratio; 95% confidence interval: 1.17-1.41), CTSD (1.15-1.37), CD163 (1.09-1.30), IGFBP2 (1.05-1.30), and FABP4 (1.04-1.29)] and ACM and four proteins [GAL4 (1.38-1.56), CTSD (1.14-1.43), CD163 (1.09-1.36), and IGFBP2 (1.03-1.35)] with CVM. Three proteins [GAL4 (1.14-1.57), CTSD (1.12-1.50), and FABP4 (1.05-1.55)] were significantly associated with incident CE and two [GAL4 (1.03-1.54) and CTSD (1.01-1.46)] were associated with incident HF after adjusting for traditional risk factors including N-terminal pro-brain natriuretic peptide.CONCLUSIONS: In a general Swedish population, four proteins previously shown to be associated with diabetes were associated with ACM and CVM. Three proteins were associated with incident CE. Finally, GAL4 and CTSD displayed novel associations with incident HF and were the only proteins associated with all outcomes.

KW - Cardiometabolic disease

KW - Cardiovascular disease

KW - Cathepsin D

KW - Diabetes

KW - Galectin-4

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=85092354386&partnerID=8YFLogxK

U2 - 10.1002/ehf2.13036

DO - 10.1002/ehf2.13036

M3 - Journal article

C2 - 33047884

VL - 7

SP - 4151

EP - 4158

JO - E S C Heart Failure

JF - E S C Heart Failure

SN - 2055-5822

IS - 6

ER -

ID: 61957689