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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Prostate needle biopsies: interobserver variation and clinical consequences of histopathological re-evaluation

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  1. Primary antibiotic resistance of Helicobacter pylori strains among adults and children in a tertiary referral centre in Lithuania

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  2. A short history of microbial biofilms and biofilm infections

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  3. Biofilms and host response - helpful or harmful

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  4. Diagnosis of biofilm infections in cystic fibrosis patients

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  1. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

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  2. Postembolization Syndrome after Prostatic Artery Embolization: A Systematic Review

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  3. AZGP1 Protein Expression in Hormone-Naïve Advanced Prostate Cancer Treated with Primary Androgen Deprivation Therapy

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  4. Genotype-phenotype associations in PPGLs in 59 patients with variants in SDHX genes

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  5. Validation of the four-miRNA biomarker panel MiCaP for prediction of long-term prostate cancer outcome

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Histopathological grading of prostate cancer (PCa) is associated with significant interobserver variability. This, as well as clinical consequences of histopathological re-evaluation, was investigated. In 350 patients, histopathological re-evaluations of prostate biopsies were compared with primary pathology reports and with histopathology of the radical prostatectomy specimen. The consequences of re-evaluation for clinical workup and treatment of patients according to local algorithms were determined. For Gleason score (GS), complete agreement between primary report and re-evaluation was found in 76.9%. The cancers were assessed with higher GS at re-evaluation in 25.0% of patients in cases with primary GS ≤ 6, while scores were devaluated in 3.0% and 10.3% of the patients with primary GS = 7 and ≥ 8, respectively. Strategies for clinical evaluation and treatment were changed as a result of the biopsy re-evaluations in 19.7% and 13.1% of patients, respectively. Gleason scoring based on the radical prostatectomy specimen was higher than in both primary reports and re-evaluation of biopsies. Although a relatively high degree of concordance was found between biopsy assessments, the significant trend towards higher Gleason scoring at re-evaluation, leading to frequent changes in clinical assessments and surgical strategy, justifies re-evaluation of PCa biopsies in patients with primary GS ≤ 6.
Original languageEnglish
JournalActa Pathologica Microbiologica et Immunologica Scandinavica
Volume119
Issue number4-5
Pages (from-to)239-46
Number of pages8
ISSN0903-4641
DOIs
Publication statusPublished - 2011

    Research areas

  • Adenocarcinoma, Biopsy, Needle, Cohort Studies, Denmark, Humans, Lymph Node Excision, Male, Neoplasm Staging, Observer Variation, Prostatectomy, Prostatic Neoplasms, Referral and Consultation

ID: 33229586