Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Prospective evaluation of acute toxicity and patient reported outcomes in anal cancer and plan optimization

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Diffusion MRI outlined viable tumour volume beats GTV in intra-treatment stratification of outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diabetes increases the risk of serious adverse events after re-irradiation of the spine

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Udredning og behandling af analcancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tumour-infiltrating lymphocyte scores effectively stratify outcomes over and above p16 post chemo-radiotherapy in anal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. KRAS and BRAF mutations in anal carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND AND PURPOSE: Chemoradiotherapy (CRT) is the standard therapy for localized anal cancer (AC), but this treatment is associated with substantial toxicity. However, there is a lack of prospectively collected toxicity and patient reported outcome (PRO) data from larger cohorts. The purpose was to prospectively collect and determine agreement between physician assessed toxicity (CTCAE) and PRO during and after CRT and to compare IMRT, VMAT and proton-based planning in a subgroup of patients.

MATERIAL AND METHODS: Patients, treated with CRT for AC, were included between 2015 and 2017. NCI-CTCAE v.4.0, EORTC QLQ-C30 and CR29 data were collected baseline, mid-therapy, end-of therapy and 2-4 weeks posttherapy. Treatment planning with 5- or 6-fixed field IMRT, 2 and 3 arc VMAT, and 3- and 4-field proton plans were compared.

RESULTS: One-hundred patients were included. Both CTCAE and PROs related to acute toxicity reached a maximum at end of therapy. Incidences of PROs were markedly higher with only slight to fair agreement to CTCAE, (κ 13-37). Comparative planning revealed dosimetric equality of IMRT and VMAT plans, but superiority of proton plans.

CONCLUSIONS: The high incidence of PRO scores and weak agreement to CTCAE suggest that PROs are important tools complementary to CTCAE in evaluating patient symptoms during and after CRT. Proton therapy has the potential to lower radiation doses to most organs at risk.

Original languageEnglish
JournalRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume128
Issue number2
Pages (from-to)375-379
Number of pages5
ISSN0167-8140
DOIs
Publication statusPublished - Aug 2018

    Research areas

  • Aged, Anal Canal/drug effects, Anus Neoplasms/therapy, Chemoradiotherapy/adverse effects, Female, Humans, Male, Middle Aged, Patient Reported Outcome Measures, Prospective Studies, Protons, Quality of Life, Radiometry, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted/methods, Radiotherapy, Intensity-Modulated/adverse effects

ID: 56565148