Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

43 Citations (Scopus)

Abstract

Depression is accompanied by an inflammatory reaction and activation of cell mediated immunity (CMI) and stressors may induce the cytokine network in humans. The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain.
Original languageEnglish
JournalJournal of Affective Disorders
Volume136
Issue number1-2
Pages (from-to)134-8
Number of pages5
ISSN0165-0327
DOIs
Publication statusPublished - 2012

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