Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

Eva Haastrup; Jens Otto Drachmann Bukh; Camilla Bock; Maj Vinberg; Lise Wegner Thørner; Thomas Hansen; Thomas Werge; Lars Vedel Kessing; Henrik Ullum

doi:10.1016/j.jad.2011.08.025

Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

Eva Haastrup, Jens Otto Drachmann Bukh, Camilla Bock, Maj Vinberg, Lise Wegner Thørner, Thomas Hansen, Thomas Werge, Lars Vedel Kessing, Henrik Ullum

42 Citations (Scopus)

Abstract

Depression is accompanied by an inflammatory reaction and activation of cell mediated immunity (CMI) and stressors may induce the cytokine network in humans. The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain.

Original language	English
Journal	Journal of Affective Disorders
Volume	136
Issue number	1-2
Pages (from-to)	134-8
Number of pages	5
ISSN	0165-0327
DOIs	https://doi.org/10.1016/j.jad.2011.08.025
Publication status	Published - 2012

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10.1016/j.jad.2011.08.025

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title = "Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events",

abstract = "Depression is accompanied by an inflammatory reaction and activation of cell mediated immunity (CMI) and stressors may induce the cytokine network in humans. The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain.",

author = "Eva Haastrup and Bukh, {Jens Otto Drachmann} and Camilla Bock and Maj Vinberg and Th{\o}rner, {Lise Wegner} and Thomas Hansen and Thomas Werge and Kessing, {Lars Vedel} and Henrik Ullum",

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T1 - Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

AU - Haastrup, Eva

AU - Bukh, Jens Otto Drachmann

AU - Bock, Camilla

AU - Vinberg, Maj

AU - Thørner, Lise Wegner

AU - Hansen, Thomas

AU - Werge, Thomas

AU - Kessing, Lars Vedel

AU - Ullum, Henrik

PY - 2012

Y1 - 2012

N2 - Depression is accompanied by an inflammatory reaction and activation of cell mediated immunity (CMI) and stressors may induce the cytokine network in humans. The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain.

AB - Depression is accompanied by an inflammatory reaction and activation of cell mediated immunity (CMI) and stressors may induce the cytokine network in humans. The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain.

U2 - 10.1016/j.jad.2011.08.025

DO - 10.1016/j.jad.2011.08.025

M3 - Journal article

C2 - 21962565

VL - 136

SP - 134

EP - 138

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-2

ER -

Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

Abstract

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