Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Tetsushi Kaneko; Masahiro Itoh; Yoichi Nakamura; Akira Iimura; Shogo Hayashi; Kodo Takahashi; Franca Stivala; Klaus Bendtzen; Ferdinando Nicoletti

Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Tetsushi Kaneko
, Masahiro Itoh
, Yoichi Nakamura
, Akira Iimura
, Shogo Hayashi
, Kodo Takahashi
, Franca Stivala
, Klaus Bendtzen
, Ferdinando Nicoletti

13 Citations (Scopus)

Abstract

We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

Original language	English
Journal	Cytokine
Volume	22
Issue number	1-2
Pages (from-to)	50-3
Number of pages	4
ISSN	1043-4666
Publication status	Published - 1 Apr 2003

Cite this

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abstract = "We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.",

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AU - Kaneko, Tetsushi

AU - Itoh, Masahiro

AU - Nakamura, Yoichi

AU - Iimura, Akira

AU - Hayashi, Shogo

AU - Takahashi, Kodo

AU - Stivala, Franca

AU - Bendtzen, Klaus

AU - Nicoletti, Ferdinando

PY - 2003/4/1

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N2 - We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

AB - We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

UR - https://www.sciencedirect.com/science/article/abs/pii/S1043466603001030?via%3Dihub

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Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Abstract

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