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Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis

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With the discovery that the highly effective anti-CD20 antibody therapies developed to deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological properties of CD20+ T cells has emerged. In this study we show that CD20+ T cells have a proinflammatory Th1/Tc1 phenotype with a high proliferative capacity to CNS antigens. We also found that the percentage of CD20+ T cells is increased in the blood of patients with multiple sclerosis and are enriched in the CSF of the patients. Furthermore, we found a positive correlation between CD20+ T cells in the CSF and multiple sclerosis disease severity and see that regulation of CD20+ T cells likely contributes to the positive treatment effect of the multiple sclerosis treatment alemtuzumab. These data represent an important contribution to the understanding of the nature of CD20+ T cells and strongly suggests a role of CD20+ T cells in the pathogenesis of multiple sclerosis.

Original languageEnglish
JournalBrain : a journal of neurology
Volume142
Issue number1
Pages (from-to)120-132
Number of pages13
ISSN0006-8950
DOIs
Publication statusPublished - 1 Jan 2019

    Research areas

  • Adult, Alemtuzumab/therapeutic use, Antigens, CD20/blood, Cell Proliferation/drug effects, Cytokines/metabolism, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis/blood, Multiple Sclerosis, Chronic Progressive/blood, T-Lymphocytes/drug effects, Young Adult

ID: 57911466